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Effect of high-fat, low-carbohydrate enteral formula versus standard enteral formula in hyperglycemic critically ill patients: a randomized clinical trial

  • Davoud Vahabzadeh
  • Mohammad Amin Valizadeh Hasanloei
  • Zahra Vahdat ShariatpanahiEmail author
Original Article
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Abstract

High-fat, low-carbohydrate diets may attenuate the hyperglycemia in critically ill patients. This study was performed to compare the effects of high-fat, low-carbohydrate enteral nutrition on glycemic control and clinical outcomes in new identified hyperglycemic patients. Eighty-eight new identified hyperglycemic patients with no history of diabetes or diagnosed hyperglycemia were randomly allocated to a standard (protein 20%, fat 30%, and carbohydrate 50%) or high-fat (protein 20%, fat as equal amount of olive and sunflower 45%, and carbohydrate 35%) kitchen formulas. Duration of intervention was 15 days. Baseline characteristics of patients were the same. Forty-one patients in the high fat and 39 patients in the standard group completed the study. Mean blood glucose, mean infused insulin, final blood glucose, and final infused insulin were not differed significantly between groups. Repeated measure showed that the average blood glucose declined in the high-fat formula group, as well as standard one, but with more decline at the end of the first week, and with a higher rate in the high-fat formula group. The mean blood triglyceride level on the final day was lower in the high-fat formula group (p = 0.001). There were no significant differences between groups in clinical outcomes. Although the high-fat formula declined blood glucose and triglyceride levels more than the standard group, yet the decrease in blood glucose was not significant. Also, it has no significant effect on clinical outcomes.

Keywords

Olive Lipid ICU Ventilator 

Notes

Acknowledgments

Our thanks go to Shahid Beheshti University of Medical Science and Urmia University of Medical Science Vice Chancellor of Research and Technology for their help in providing study field and giving study ethics approval for execution. Thanks to all patients guardians, nurses, staff, physicians, and ICU attendants for their cooperation in the study protocol accomplishment.

Funding information

Funding of this study was provided by the Urmia University of Medical Sciences.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of informed consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Research Society for Study of Diabetes in India 2018

Authors and Affiliations

  • Davoud Vahabzadeh
    • 1
    • 2
  • Mohammad Amin Valizadeh Hasanloei
    • 3
  • Zahra Vahdat Shariatpanahi
    • 4
    Email author
  1. 1.Deptartment of Clinical Nutrition, Faculty of Nutrition and Food TechnologyInternational Branch of Shahid Beheshti University of Medical SciencesTehranIran
  2. 2.Patient Safety Research CenterUrmia University of Medical SciencesUrmiaIran
  3. 3.Department of Anesthesiology and Critical Care, Emam Khomeini HospitalUrmia University of Medical SciencesUrmiaIran
  4. 4.Deptartment of Clinical Nutrition, Faculty of Nutrition and Food TechnologyShahid Beheshti University of Medical ScienceTehranIran

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