Familial history: a risk factor of type 2 diabetes among the “Aggarwal” population of Delhi, India
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Anthropologically, the majority of Indian population structure could be discerned in terms of different endogamous population groups (who marry between the clans), but unfortunately we still remain unaware about the epidemiological burden of type 2 diabetes (T2D) among different endogamous groups in India. We assessed the effect of family history on the risk of T2D among the Aggarwal (endogamous caste group) population of Delhi, a hospital-based case-control association study among the target population group of Delhi. Sixty percent of the cases reported familial history of type 2 diabetes. We found that the family history of T2D among Aggarwals significantly increases the odds of disease to 2.3 (confidence interval; 1.5041 to 3.5077). Cultural hallmarks, e.g., sedentary lifestyle, high socioeconomic status, and fat-enriched vegetarian dietary habits (86 %; pure-vegetarian) were noted in the present population. These factors correlated with age, waist to hip ratio, and blood pressure, which were important indicators for T2D in our study. The family history is a pertinent risk factor of T2D in this population group and can robustly predict the risk of T2D in their family and kinship. We suggest that the familial history of diabetes can be used as a potential public health tool for conducting population and culture-based epidemiological surveys that are required for better understanding of susceptibility to type 2 diabetes.
KeywordsType 2 diabetes Aggarwals Endogamous population Family history
We are thankful to Department of Anthropology, University of Delhi, for providing the required support,and study population for thier cooperation in carrying out this research work.
Conflict of interest
We declare authors of this manuscript have no conflict of interest.
Vipin Gupta contributed to the research design, field-work, analysis, and paper writing; Rajesh Khadgawat contributed to the research design, field-work, and paper writing; H.K. Tony Ng contributed to the data analysis; M. P. Sachdeva contributed to the research design, field-work, and paper writing. The manuscript has been read and approved by all the authors, that the requirements for authorship as required by the journal have been met, and that each author believes that the manuscript represents honest work.
Source of support
Research Fellowship of Indian Council of Medical Research
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