Comparison of salivary nitric oxide and epidermal growth factor level between diabetic patients and healthy individuals

  • Hamid Reza Abdolsamadi
  • Fatemeh Rezaei
  • Mohammad Taghi Goodarzi
  • Abbas Moghimbeigi
  • Mina Jazaeri
  • Soheila Asadi
  • Fatemeh Ahmadi-MotamayelEmail author
Original Article


The purpose of the current study was to compare salivary Nitric oxide and epidermal growth factor level in diabetic patients and healthy individuals. In this paired-control study 20 patients with type 1 diabetes mellitus, 20 patients with type 2 diabetes mellitus and 20 age and sex matched healthy subjects participated. The level of salivary Nitric oxide was increased in type 1 and 2 diabetic patients in comparison to control individuals (P = 0.037 and P = 0.058), respectively. Epidermal growth factor concentration was higher in type 1 and 2 diabetic patients compare to healthy ones, (P = 0.037 and P = 0.005) respectively. There was no significant difference between salivary Nitric oxide and Epidermal growth factor level regarding to the type of diabetes (P > 0.05). Significant statistical correlation was found between Nitric oxide and Epidermal growth factor levels and the fasting blood glucose and HbA1c (P < 0.001). Conclusions: Salivary Nitric oxide and Epidermal growth factor levels were higher in type 1 and type 2 diabetic patients and there was correlation with severity of disease.


Type 1 diabetes mellitus Type 2 diabetes mellitus Biomarker 



This article is a part of thesis supported by Hamadan University of Medical Sciences. We would like to thank Deputy of Education as well as Deputy of Research and Technology of Hamadan University of Medical Sciences for financial support of this study. The authors would like to thank Dr Zeynab Parvizi for English editing of this article.

Conflict of Interests

The authors declare that they have no conflicts of interest.


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Copyright information

© Research Society for Study of Diabetes in India 2014

Authors and Affiliations

  • Hamid Reza Abdolsamadi
    • 1
  • Fatemeh Rezaei
    • 2
  • Mohammad Taghi Goodarzi
    • 3
  • Abbas Moghimbeigi
    • 4
  • Mina Jazaeri
    • 5
  • Soheila Asadi
    • 6
  • Fatemeh Ahmadi-Motamayel
    • 7
    Email author
  1. 1.Dental Research Center - Department of Oral Medicine, School of DentistryHamadan University of Medical SciencesHamadanIran
  2. 2.Department of Oral Medicine, School of DentistryKermanshah University of Medical SciencesKermanshahIran
  3. 3.Research Center for Molecular Medicine, School of MedicineHamadan University of Medical SciencesHamadanIran
  4. 4.Department of Biostatistic, School of Public HealthHamadan University of Medical SciencesHamadanIran
  5. 5.Department of Oral Medicine, School of DentistryHamadan University of Medical SciencesHamadanIran
  6. 6.Department of Biochemistry, School of MedicineHamadan University of Medical SciencesHamadanIran
  7. 7.Research Center for Molecular Medicine, Department of Oral Medicine, Dental SchoolHamadan University of Medical SciencesHamadanIran

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