Potential effect of insulin resistance and cardiovascular risk factors on metabolic syndrome in subjects with normal fasting plasma glucose levels

  • Dong Wook Jeong
  • Jeong Gyu Lee
  • Sangyeoup Lee
  • Yun Jin Kim
  • Jae Ho Bae
  • Dong Hee Kim
  • Yu Hyeon Yi
  • Young Hye Cho
  • Uisoo Chae
Original Article
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Abstract

The prevalence of metabolic syndrome has progressively increased with increasing fasting plasma glucose (FPG) levels. This study aimed to investigate the influence of insulin resistance and cardiovascular risk factors on metabolic syndrome in individuals with normal FPG. Study subjects with FPG levels below 100 mg/dL were divided into 5 groups depending on the exact FPG levels. We then evaluated the association of metabolic syndrome with insulin resistance and total cholesterol/ high density lipoprotein-cholesterol ratio (TC/HDL ratio). The odds ratio of insulin resistance in the level of HOMA-IR above 2.34 group [3.483(95 % CI, 1.110 ∼ 10.932)] was significantly increased in the group of FPG level from 93 mg/dL to 99 mg/dL compared to the group below 80 mg/dL. The odds ratio of metabolic syndrome in the group of FPG level from 89 mg/dL to 92 mg/dL [2.459, (95%CI, 1.275 ∼ 4.741)] and 93 mg/dL to 99 mg/dL [2.079, (95%CI, 1.052 ∼ 4.110)] was significantly increased compared to the group below 80 mg/dL after adjusting age, sex, smoking status, physical activity, heavy drinking, TC/HDL ratio. Higher FPG levels within the normoglycemic range may constitute a risk of insulin resistance and is associated more strongly with the risks of metabolic syndrome.

Keywords

Blood glucose Metabolic syndrome Insulin resistance Cholesterol Glucose intolerance 

Copyright information

© Research Society for Study of Diabetes in India 2012

Authors and Affiliations

  • Dong Wook Jeong
    • 1
  • Jeong Gyu Lee
    • 1
  • Sangyeoup Lee
    • 1
    • 2
  • Yun Jin Kim
    • 1
  • Jae Ho Bae
    • 3
  • Dong Hee Kim
    • 4
  • Yu Hyeon Yi
    • 1
  • Young Hye Cho
    • 1
  • Uisoo Chae
    • 5
  1. 1.Center for Obesity, Nutrition and Metabolism, Department of Family Medicine and Medical Research InstitutePusan National University School of Medicine, Pusan National University HospitalBusanSouth Korea
  2. 2.Medical Education UnitPusan National University School of MedicineBusanSouth Korea
  3. 3.Department of BiochemistryPusan National University School of MedicineBusanSouth Korea
  4. 4.College of NursingPusan National UniversityBusanSouth Korea
  5. 5.Pusan National University School of MedicineBusanSouth Korea

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