Gold Bulletin

, Volume 52, Issue 1, pp 9–17 | Cite as

Development of a novel thermo-responsive hydrogel-coated gold nanorods as a drug delivery system

  • Mehran KurdtabarEmail author
  • Gazal Baghestani
  • Ghasem Rezanejade BardajeeEmail author
Original Paper


In this study, at first, gold nanorods (GNRs) were synthesized and then they were coated with a layer of hydrogel composed of poly(N-isopropylacrylamide) (PNIPAM) grafted onto carboxymethyl cellulose (CMC) as a backbone. The chemical structure of GNRs/PNIPAM-g-CMC hydrogel was characterized by Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), atomic-force microscopy (AFM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The swelling properties of the obtained GNRs/PNIPAM-g-CMC hydrogel were studied at different times and temperatures. In addition, drug release from doxorubicin-loaded GNRs/PNIPAM-g-CMC hydrogel was examined at different temperatures during time. The drug release mechanism was studied by first-order, second-order, and Ritger–Peppas models. Finally, the GNRs/PNIPAM-g-CMC hydrogel biocompatibility was tested against L929 mouse fibroblast cells by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method. Our study suggests that GNRs coated with low-cost hydrogels can be excellent candidate for drug delivery systems.


Gold nanorod Drug delivery Hydrogel Carboxymethyl cellulose N-isopropyl acrylamide 


Funding information

This work was funded by the Karaj Islamic Azad University, PNU, and INSF.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceIslamic Azad University, Karaj BranchKarajIran
  2. 2.Department of ChemistryPayame Noor UniversityTehranIran

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