Cellular Oncology

, Volume 35, Issue 5, pp 317–334 | Cite as

Aberrant microRNA expression and its implications in the pathogenesis of leukemias

Review

Abstract

Background

MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias.

Aim

Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL).

Conclusions

The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.

Keywords

MicroRNA Expression signature Acute myeloid leukemia Acute lymphoblastic leukemia Chronic myeloid leukemia Chronic lymphocytic leukemia 

Abbreviations

MiRNAs

MicroRNAs

AML

Acute myeloid leukemia

CN-AML

Cytogenetically normal acute myeloid leukemia

ALL

Acute lymphoblastic leukemia

CLL

Chronic lymphocytic leukemia

CML

Chronic myeloid leukemia

Ph

Philadelphia chromosome

BM

Bone marrow

USF2

Upstream transcription factor 2

BCL-2

B-cell leukemia/lymphoma-2

E2F-1

E2 transcription factor family-1

TCL-1

T-cell leukemia/lymphoma1

MCL-1

Myeloid cell leukemia 1

Itch

Itchy E3 ubiquitin protein ligase homolog

C/EBPα

CCAAT/enhancer binding protein alpha

PLK2

Polo-like kinase 2

AE

AML1/ETO

FLT3-ITD

Internal tandem duplication of FMS-like tyrosine kinase 3

HOX

Homeobox

MEIS1

Myeloid ecotropic viral integration site 1

c-Kit

v-Kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog

CNS

Central nervous system

MDR

Minimally-deleted region

DLEU

Deleted in leukemia

DLBCL

Diffuse large B-cell lymphoma

MBL

Monoclonal B-cell lymphocytosis

IgVH

Immunoglobulin heavy-chain variable-region

ZAP-70

70-kDa zeta-associated protein

LPL

Lipoprotein lipase

qRT-PCR

Quantitative real-time polymerase chain reaction

OS

Overall survival

TFS

Treatment-free survival

OG

Oncogene

TS

Tumor suppressor

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Copyright information

© International Society for Cellular Oncology 2012

Authors and Affiliations

  • Sadegh Babashah
    • 1
  • Majid Sadeghizadeh
    • 1
  • Mostafa Rezaei Tavirani
    • 2
  • Shirin Farivar
    • 3
  • Masoud Soleimani
    • 4
  1. 1.Department of Molecular Genetics, Faculty of Biological SciencesTarbiat Modares UniversityTehranIran
  2. 2.Proteomics Research Center, Faculty of Paramedical SciencesShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Faculty of Biological SciencesShahid Beheshti University, G.C.TehranIran
  4. 4.Department of Hematology, School of Medical SciencesTarbiat Modares UniversityTehranIran

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