Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus
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Ischemic stroke is a rare complication of varicella-zoster virus (VZV) infection. We present the case of a patient with a medical history of type 2 diabetes mellitus (DM) who experienced disseminated cutaneous VZV infection followed by multiple cerebral infarcts associated with VZV vasculopathy. Brain magnetic resonance imaging revealed multiple hyperintense lesions over the bilateral deep white matter and basal ganglia. A skin biopsy revealed small-vessel leukocytoclastic vasculitis with neutrophilic, lymphocytic, and eosinophilic infiltration. This case report describes the rare finding of cutaneous leukocytoclastic vasculitis in VZV infection and highlights that VZV infection is an uncommon but critical etiology of cryptogenic stroke in patients with DM.
KeywordsDiabetes mellitus Varicella-zoster virus Vasculitis Vasculopathy Stroke
Varicella zoster virus
Magnetic resonance imaging
Fluid-attenuated inversion recovery
This manuscript was edited by Wallace Academic Editing.
Compliance with ethical standards
The study was approved by the Taipei Medical University Joint Institutional Review Board (No. N20190387).
Conflict of interest
The authors declare that they have no conflict of interest.
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