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Human adenovirus meningoencephalitis: a 3-years’ overview

  • Luine Rosele Vidal
  • Sérgio Monteiro de AlmeidaEmail author
  • Bárbara Maria Cavalli
  • Tatiana Gutierrez Dieckmann
  • Sonia Mara Raboni
  • Gabriel L. O. Salvador
  • Luciane Aparecida Pereira
  • Indianara Rotta
  • Meri Bordignon Nogueira
Article
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Abstract

Human adenovirus (HAdV) has been recognized as a significant viral pathogen implicated in neurological diseases, particularly in immunocompromised patients. However, its involvement in meningoencephalitis remains unclear. The aim of this study was to investigate HAdV and other viral co-infections in the cerebrospinal fluid (CSF) of patients suspected of having either meningoencephalitis or encephalitis. A total of 373 CSF samples from patients under clinical suspicion of neurological viral infection were included in this study. HAdV was investigated by conventional or multiplex real-time PCR, for different time periods. The frequency of HAdV central nervous system (CNS) infection was 1.08%, predominating in female patients with a predisposing condition, and presented with HAdV encephalitis. HAdV CNS infection was found to occur during the months of autumn and winter. The frequency of HAdV detected in CSF positive samples increased after the change in the diagnostic method from conventional to multiplex real-time PCR. There were no specific NMRI or EEG characteristics and two CSF samples with HAdV encephalitis had normal CSF WBC count. There were two cases of co-infection with HIV; no other co-infections with enterovirus or herpes family viruses were detected. All patients had good outcome. Although HAdV is rarely observable in CNS infectious syndromes, it must be investigated particularly in immunocompromised patients.

Keywords

Adenovirus Viral meningoencephalitis CSF Nervous system 

Notes

Authors’ contributions

Sérgio Monteiro de Almeida: literature search, figures, study design, data collection, data analysis, data interpretation, writing.

Luine Rosele Renaud Vidal: literature search, figures, study design, data collection, data analysis, data interpretation, writing.

Bárbara Maria Cavalli: literature search, data collection, data analysis.

Tatiana Gutierrez Dieckmann: data collection.

Sonia Mara Raboni: study design.

Gabriel L.O. Salvador: neuroimage data collection and interpretation.

Luciane Aparecida Pereira: data collection.

Indianara Rotta: data collection.

Meri Bordignon Nogueira: literature search, figures, study design, data collection, data analysis, data interpretation, writing.

Compliance with ethical standards

Conflict of interest

Luine Rosele Renaud Vidal declares no conflict of interest.

Sérgio Monteiro de Almeida declares no conflict of interest.

Bárbara Maria Cavalli declares no conflict of interest.

Tatiana Gutierrez Dieckmann declares no conflict of interest.

Sonia Mara Raboni declares no conflict of interest.

Gabriel L.O. Salvador declares no conflict of interest.

Luciane Aparecida Pereira declares no conflict of interest.

Indianara Rotta declares no conflict of interest.

Meri Bordignon Nogueira declares no conflict of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2019

Authors and Affiliations

  • Luine Rosele Vidal
    • 1
  • Sérgio Monteiro de Almeida
    • 1
    Email author
  • Bárbara Maria Cavalli
    • 1
  • Tatiana Gutierrez Dieckmann
    • 1
  • Sonia Mara Raboni
    • 1
  • Gabriel L. O. Salvador
    • 2
  • Luciane Aparecida Pereira
    • 1
  • Indianara Rotta
    • 1
  • Meri Bordignon Nogueira
    • 1
  1. 1.Virology Laboratory, Clinical Pathology Laboratory - Hospital de ClínicasUniversidade Federal do ParanáCuritibaBrazil
  2. 2.Radiology Unity-Hospital de Clínicas, UFPRComplexo Hospital de Clínicas da Universidade Federal do ParanáCuritibaBrazil

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