Human adenovirus meningoencephalitis: a 3-years’ overview
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Human adenovirus (HAdV) has been recognized as a significant viral pathogen implicated in neurological diseases, particularly in immunocompromised patients. However, its involvement in meningoencephalitis remains unclear. The aim of this study was to investigate HAdV and other viral co-infections in the cerebrospinal fluid (CSF) of patients suspected of having either meningoencephalitis or encephalitis. A total of 373 CSF samples from patients under clinical suspicion of neurological viral infection were included in this study. HAdV was investigated by conventional or multiplex real-time PCR, for different time periods. The frequency of HAdV central nervous system (CNS) infection was 1.08%, predominating in female patients with a predisposing condition, and presented with HAdV encephalitis. HAdV CNS infection was found to occur during the months of autumn and winter. The frequency of HAdV detected in CSF positive samples increased after the change in the diagnostic method from conventional to multiplex real-time PCR. There were no specific NMRI or EEG characteristics and two CSF samples with HAdV encephalitis had normal CSF WBC count. There were two cases of co-infection with HIV; no other co-infections with enterovirus or herpes family viruses were detected. All patients had good outcome. Although HAdV is rarely observable in CNS infectious syndromes, it must be investigated particularly in immunocompromised patients.
KeywordsAdenovirus Viral meningoencephalitis CSF Nervous system
Sérgio Monteiro de Almeida: literature search, figures, study design, data collection, data analysis, data interpretation, writing.
Luine Rosele Renaud Vidal: literature search, figures, study design, data collection, data analysis, data interpretation, writing.
Bárbara Maria Cavalli: literature search, data collection, data analysis.
Tatiana Gutierrez Dieckmann: data collection.
Sonia Mara Raboni: study design.
Gabriel L.O. Salvador: neuroimage data collection and interpretation.
Luciane Aparecida Pereira: data collection.
Indianara Rotta: data collection.
Meri Bordignon Nogueira: literature search, figures, study design, data collection, data analysis, data interpretation, writing.
Compliance with ethical standards
Conflict of interest
Luine Rosele Renaud Vidal declares no conflict of interest.
Sérgio Monteiro de Almeida declares no conflict of interest.
Bárbara Maria Cavalli declares no conflict of interest.
Tatiana Gutierrez Dieckmann declares no conflict of interest.
Sonia Mara Raboni declares no conflict of interest.
Gabriel L.O. Salvador declares no conflict of interest.
Luciane Aparecida Pereira declares no conflict of interest.
Indianara Rotta declares no conflict of interest.
Meri Bordignon Nogueira declares no conflict of interest.
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