Recurrent strokes, central nervous system vasculitis, and acquired protein S deficiency secondary to varicella zoster in a child with AIDS
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A child with vertical transmission of human immunodeficiency virus refractory to therapy developed zoster-induced protein S deficiency and recurrent strokes. Extensive carotid arteritis was found postmortem. The carotid tissue was positive for herpes varicella zoster by polymerase chain reaction, as were immunofixation stains of the arterial wall.
KeywordsZoster AIDS Arteritis Protein S Strokes
The authors would like to thank Steven Lovrich, Ph.D., Gundersen Health System; Scott Cooper, Ph.D., University of Wisconsin – La Crosse; and Bernadette Taylor, Ph.D., University of Wisconsin – La Crosse.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Fair DS, Marlar RA, Levin EG (1986) Human endothelial cells synthesize protein S. Blood 67:1168–1171Google Scholar
- Gilden DH, Kleinschmidt-DeMasters BK, Wellish M, Hedley-Whyte ET, Rentier B, Mahalingam R (1996) Varicella zoster virus, a cause of waxing and waning vasculitis: The New England Journal of Medicine case 5-1995 revisited. Neurology 47:1441–1446. https://doi.org/10.1212/WNL.47.6.1441 CrossRefGoogle Scholar
- Harbecke R, Oxman MN, Arnold BA, Ip C, Johnson GR, Levin MJ, Gelb LD, Schmader KE, Straus SE, Wang H, Wright PF, Pachucki CT, Gershon AA, Arbeit RD, Davis LE, Simberkoff MS, Weinberg A, Williams HM, Cheney C, Petrukhin L, Abraham KG, Shaw A, Manoff S, Antonello JM, Green T, Wang Y, Tan C, Keller PM, Shingles Prevention Study Group (2009) A real-time PCR assay to identify and discriminate among wild-type and vaccine strains of varicella-zoster virus and herpes simplex virus in clinical specimens, and comparison with the clinical diagnoses. J Med Virol 81:1310–1322. https://doi.org/10.1002/jmv.21506 CrossRefGoogle Scholar