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Journal of NeuroVirology

, Volume 23, Issue 4, pp 615–620 | Cite as

Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient

  • A. VelayEmail author
  • W. Kack-Kack
  • F. Abravanel
  • S. Lhomme
  • P. Leyendecker
  • L. Kremer
  • P. Chamouard
  • J. Izopet
  • S. Fafi-Kremer
  • H. Barth
Case Report

Abstract

Hepatitis E virus (HEV) infection is an emerging autochthonous disease in industrialized countries. Extra-hepatic manifestations, in particular neurologic manifestations, have been reported in HEV infection. Only a few cases of hepatitis E-associated Parsonage-Turner syndrome have been reported, and HEV genotypes were rarely determined. Here, we report the case of a Parsonage-Turner syndrome associated with an acute autochthonous HEV infection in a 55-year-old immunocompetent patient. HEV genomic RNA was detected in serum and cerebrospinal fluid samples (CSF), and molecular phylogenetic analysis of HEV was performed. The interest of this case lies in its detailed description notably the molecular analysis of HEV RNA isolated from serum and CSF. HEV infection should be considered in diagnostic investigations of neurologic manifestations associated with liver function perturbations.

Keywords

Hepatitis E Neurological disorders Parsonage-Turner syndrome Neuralgic amyotrophy 

Notes

Compliance with ethical standards

Funding

None declared.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Approval of an ethics committee was not required for this study.

Supplementary material

13365_2017_525_MOESM1_ESM.docx (181 kb)
ESM 1 (DOCX 180 kb)

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Copyright information

© Journal of NeuroVirology, Inc. 2017

Authors and Affiliations

  • A. Velay
    • 1
    • 2
    Email author
  • W. Kack-Kack
    • 1
    • 2
  • F. Abravanel
    • 3
    • 4
  • S. Lhomme
    • 3
    • 4
  • P. Leyendecker
    • 5
  • L. Kremer
    • 6
    • 7
  • P. Chamouard
    • 8
  • J. Izopet
    • 3
    • 4
  • S. Fafi-Kremer
    • 1
    • 2
  • H. Barth
    • 1
    • 2
  1. 1.Virology LaboratoryUniversity Hospital of StrasbourgStrasbourgFrance
  2. 2.INSERM, IRM UMR-S 1109StrasbourgFrance
  3. 3.INSERM, U1043, Centre de Physiopathologie de Toulouse PurpanToulouseFrance
  4. 4.CHU Toulouse Hôpital Purpan, Laboratoire de virologieInstitut fédératif de biologie de PurpanToulouseFrance
  5. 5.Department of NeuroradiologyUniversity Hospital of StrasbourgStrasbourgFrance
  6. 6.Service de NeurologieHôpitaux Universitaires de StrasbourgStrasbourgFrance
  7. 7.Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, UMR_S INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS)Université de StrasbourgStrasbourgFrance
  8. 8.Department of Gastroenterology and HepatologyUniversity Hospital of StrasbourgStrasbourgFrance

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