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Journal of NeuroVirology

, Volume 21, Issue 3, pp 242–248 | Cite as

Role of myeloid cells in HIV-1-host interplay

  • Mario StevensonEmail author
Article

Abstract

The AIDS research field has embarked on a bold mission to cure HIV-1-infected individuals of the virus. To do so, scientists are attempting to identify the reservoirs that support viral persistence in patients on therapy, to understand how viral persistence is regulated and to come up with strategies that interrupt viral persistence and that eliminate the viral reservoirs. Most of the attention regarding the cure of HIV-1 infection has focused on the CD4+ T cell reservoir. Investigators are developing tools to probe the CD4+ T cell reservoirs as well as in vitro systems that provide clues on how to perturb them. By comparison, the myeloid cell, and in particular, the macrophage has received far less attention. As a consequence, there is very little understanding as to the role played by myeloid cells in viral persistence in HIV-1-infected individuals on suppressive therapy. As such, should myeloid cells constitute a viral reservoir, unique strategies may be required for their elimination. This article will overview research that is examining the role of macrophage in virus-host interplay and will discuss features of this interplay that could impact efforts to eliminate myeloid cell reservoirs.

Keywords

HIV-1 Reservoirs Macrophage Eradication 

Notes

Acknowledgments

Research in the author’s lab is funded by grants MH093306, AI096109, AI088595, and MH100942 from the National Institutes of Health.

Conflict of interest

The author declares that he has no conflict of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2014

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Miami Medical SchoolMiamiUSA

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