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Journal of NeuroVirology

, Volume 20, Issue 3, pp 294–303 | Cite as

Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART

  • J. HarezlakEmail author
  • R. Cohen
  • A. Gongvatana
  • M. Taylor
  • S. Buchthal
  • G. Schifitto
  • J. Zhong
  • E. S. Daar
  • J. R. Alger
  • M. Brown
  • E. J. Singer
  • T. B. Campbell
  • D. McMahon
  • Y. T. So
  • C. T. Yiannoutsos
  • B. A. Navia
  • The HIV Neuroimaging Consortium
Article

Abstract

The reasons for persistent brain dysfunction in chronically HIV-infected persons on stable combined antiretroviral therapies (CART) remain unclear. Host and viral factors along with their interactions were examined in 260 HIV-infected subjects who underwent magnetic resonance spectroscopy (MRS). Metabolite concentrations (NAA/Cr, Cho/Cr, MI/Cr, and Glx/Cr) were measured in the basal ganglia, the frontal white matter, and gray matter, and the best predictive models were selected using a bootstrap-enhanced Akaike information criterion (AIC). Depending on the metabolite and brain region, age, race, HIV RNA concentration, ADC stage, duration of HIV infection, nadir CD4, and/or their interactions were predictive of metabolite concentrations, particularly the basal ganglia NAA/Cr and the mid-frontal NAA/Cr and Glx/Cr, whereas current CD4 and the CPE index rarely or did not predict these changes. These results show for the first time that host and viral factors related to both current and past HIV status contribute to persisting cerebral metabolite abnormalities and provide a framework for further understanding neurological injury in the setting of chronic and stable disease.

Keywords

MRS HIV dementia Neuroimaging Antiretroviral therapies HIV RNA Biomarkers 

Notes

Conflict of interest

The authors, Harezlak J, Cohen R, Gongvatana A, Taylor M, Buchthal S, Schifitto G, Zhong J, Daar ES, Alger JR, Brown M, Singer EJ, Campbell TB, McMahon D, So YT, Yiannoutsos CT, and Navia BA, declare that they have no conflict of interest.

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Copyright information

© Journal of NeuroVirology, Inc. 2014

Authors and Affiliations

  • J. Harezlak
    • 1
    Email author
  • R. Cohen
    • 2
  • A. Gongvatana
    • 3
  • M. Taylor
    • 3
  • S. Buchthal
    • 4
  • G. Schifitto
    • 5
  • J. Zhong
    • 5
  • E. S. Daar
    • 6
  • J. R. Alger
    • 7
  • M. Brown
    • 8
  • E. J. Singer
    • 7
  • T. B. Campbell
    • 8
  • D. McMahon
    • 9
  • Y. T. So
    • 10
  • C. T. Yiannoutsos
    • 1
  • B. A. Navia
    • 11
  • The HIV Neuroimaging Consortium
  1. 1.Indiana University Fairbanks School of Public HealthIndianapolisUSA
  2. 2.University of Florida College of MedicineGainesvilleUSA
  3. 3.University of California - San Diego School of MedicineLa JollaUSA
  4. 4.University of HawaiiHonoluluUSA
  5. 5.University of Rochester School of MedicineRochesterUSA
  6. 6.Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterUniversity of CaliforniaLos AngelesUSA
  7. 7.David Geffen School of Medicine at UCLALos AngelesUSA
  8. 8.University of Colorado DenverAuroraUSA
  9. 9.University of PittsburghPittsburghUSA
  10. 10.Stanford University Medical CenterPalo AltoUSA
  11. 11.Tufts University School of MedicineBostonUSA

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