Journal of NeuroVirology

, Volume 19, Issue 1, pp 10–23 | Cite as

Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study

  • Tong Zhu
  • Jianhui Zhong
  • Rui Hu
  • Madalina Tivarus
  • Sven Ekholm
  • Jaroslaw Harezlak
  • Hernando Ombao
  • Bradford Navia
  • Ron Cohen
  • Giovanni SchifittoEmail author


HIV-infected individuals with severe immune suppression are more likely to develop HIV-associated neurocognitive disorders than those with preserved immune function. While partial immune reconstitution occurs in those with severe immune suppression after starting combined antiretroviral therapy, it is not established whether improvement in immune function reverses or prevents injury to the central nervous system (CNS). To address this question, 50 participants (nadir CD4 counts ≤200 cells/mm3, on a stable antiretroviral regimen for at least 12 consecutive weeks prior to study) and 13 HIV negative participants underwent a comprehensive neurological evaluation followed by diffusion tensor imaging (DTI). Eighty-four percent of the 50 HIV participants were neurologically asymptomatic (HIVNA) and 16 % had mild cognitive impairment (HIVCI). Tract-based spatial statistics (TBSS) on DTI data revealed that mean diffusivity (MD) increased significantly in the posterior aspect of both hemispheres in HIVNA compared to controls. In HIVCI, compared to controls and HIVNA, increased MD extended to prefrontal areas. Fractional anisotropy decreased only in HIVCI, compared to either controls or HIVNA. Furthermore, DTI showed significant correlations to duration of HIV infection and significant associations with multiple cognitive domains. This study highlights that in partial immune reconstitution, injury to the CNS is present even in those that are neurologically asymptomatic and there are discrete spatial patterns of white matter injury in HIVNA subjects compared to HIVCI subjects. Our results also show that quantitative analysis of DTI using TBSS is a sensitive approach to evaluate HIV-associated white matter disease and thus valuable in monitoring central nervous system injury.


Diffusion tensor imaging HIV infection White matter injury Cognitive impairment 



The project described in this publication was supported by NS036524 and the University of Rochester CTSA award number UL1 RR024160 from the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health. The authors appreciate useful discussions with Dr. Wei Tian of the Department of Imaging Sciences at the University of Rochester.


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Copyright information

© Journal of NeuroVirology, Inc. 2012

Authors and Affiliations

  • Tong Zhu
    • 1
  • Jianhui Zhong
    • 1
  • Rui Hu
    • 2
  • Madalina Tivarus
    • 1
  • Sven Ekholm
    • 1
  • Jaroslaw Harezlak
    • 4
  • Hernando Ombao
    • 5
  • Bradford Navia
    • 6
  • Ron Cohen
    • 7
  • Giovanni Schifitto
    • 1
    • 3
    Email author
  1. 1.Department of Imaging SciencesUniversity of RochesterRochesterUSA
  2. 2.Department of Biostatistics and Computational BiologyUniversity of RochesterRochesterUSA
  3. 3.Department of NeurologyUniversity of RochesterRochesterUSA
  4. 4.Division of BiostatisticsIndiana University School of MedicineIndianapolisUSA
  5. 5.Department of StatisticsUniversity of California at IrvineIrvineUSA
  6. 6.Tufts University School of MedicineBostonUSA
  7. 7.Brown UniversityProvidenceUSA

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