Journal of NeuroVirology

, Volume 18, Issue 1, pp 62–68

Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia

  • Kathrin Held
  • Ingrid Eiglmeier
  • Susanne Himmelein
  • Inga Sinicina
  • Thomas Brandt
  • Diethilde Theil
  • Klaus Dornmair
  • Tobias Derfuss
Short Communication

DOI: 10.1007/s13365-011-0067-9

Cite this article as:
Held, K., Eiglmeier, I., Himmelein, S. et al. J. Neurovirol. (2012) 18: 62. doi:10.1007/s13365-011-0067-9

Abstract

Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.

Keywords

HSV-1 Latency CD8+ T cells Human Trigeminal ganglia 

Supplementary material

13365_2011_67_MOESM1_ESM.pdf (156 kb)
ESM 1(PDF 155 kb)

Copyright information

© Journal of NeuroVirology, Inc. 2011

Authors and Affiliations

  • Kathrin Held
    • 2
    • 3
    • 4
  • Ingrid Eiglmeier
    • 2
    • 3
  • Susanne Himmelein
    • 6
  • Inga Sinicina
    • 7
  • Thomas Brandt
    • 4
    • 6
  • Diethilde Theil
    • 4
    • 5
  • Klaus Dornmair
    • 2
    • 3
  • Tobias Derfuss
    • 1
  1. 1.Department of Neurology/Department of BiomedicineUniversity of BaselBaselSwitzerland
  2. 2.Institute of Clinical NeuroimmunologyLudwig Maximilian UniversityMunichGermany
  3. 3.Institute of NeuroimmunologyMax-Planck-Institute of NeurobiologyMartinsriedGermany
  4. 4.Department of Clinical NeurosciencesLudwig Maximilian UniversityMunichGermany
  5. 5.Novartis Institute of Biomedical ResearchBaselSwitzerland
  6. 6.IFB, Ludwig Maximilian UniversityMunichGermany
  7. 7.Department of Legal MedicineLudwig Maximilian UniversityMunichGermany

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