Journal of NeuroVirology

, Volume 17, Issue 3, pp 212–219

IL-29/IL-28A suppress HSV-1 infection of human NT2-N neurons

Article

DOI: 10.1007/s13365-011-0031-8

Cite this article as:
Zhou, L., Li, J., Wang, X. et al. J. Neurovirol. (2011) 17: 212. doi:10.1007/s13365-011-0031-8

Abstract

The newly identified cytokines, IL-28/IL-29 (also termed type III IFNs), are able to inhibit a number of viruses. Here, we examined the antiviral effects of IL-29/IL-28A against herpes simplex virus type 1 (HSV-1) in human NT2-N neurons and CHP212 neuronal cells. Both IL-29 and IL-28A could efficiently inhibit HSV-1 replication in neuronal cells, as evidenced by the reduced expression of HSV-1 DNA and proteins. This inhibitory effect of IL-29 and IL-28A against HSV-1 could be partially blocked by antibody to IL-10Rβ, one of the key receptors for IL-29 and IL-28A. To explore the underlying antiviral mechanisms employed by IL-29/IL-28A, we showed that IL-29/IL-28A could selectively induce the expression of several Toll-like receptors (TLRs) as well as activate TLR-mediated antiviral pathway, including IFN regulatory factor 7, IFN-α, and the key IFN-α stimulated antiviral genes.

Keywords

IFN HSV-1 TLR Neuron IRF-7 

Copyright information

© Journal of NeuroVirology, Inc. 2011

Authors and Affiliations

  1. 1.Department of Pathology & Laboratory MedicineTemple University School of MedicinePhiladelphiaUSA
  2. 2.Division of Histology and Embryology, Department of Anatomy, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China

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