Comparison of Different Ion Mobility Setups Using Poly (Ethylene Oxide) PEO Polymers: Drift Tube, TIMS, and T-Wave
- 455 Downloads
Over the years, polymer analyses using ion mobility-mass spectrometry (IM-MS) measurements have been performed on different ion mobility spectrometry (IMS) setups. In order to be able to compare literature data taken on different IM(-MS) instruments, ion heating and ion temperature evaluations have already been explored. Nevertheless, extrapolations to other analytes are difficult and thus straightforward same-sample instrument comparisons seem to be the only reliable way to make sure that the different IM(-MS) setups do not greatly change the gas-phase behavior. We used a large range of degrees of polymerization (DP) of poly(ethylene oxide) PEO homopolymers to measure IMS drift times on three different IM-MS setups: a homemade drift tube (DT), a trapped (TIMS), and a traveling wave (T-Wave) IMS setup. The drift time evolutions were followed for increasing polymer DPs (masses) and charge states, and they are found to be comparable and reproducible on the three instruments.
KeywordsIon mobility Mass spectrometry TIMS Drift tube Traveling wave Synthetic polymers Poly (ethylene oxide)
The authors thank the F.R.S.-FNRS for the financial support (Jean R. N. Haler and Philippe Massonnet are F.R.I.A. doctorate fellows). Bruker is acknowledged for their TIMS instrument and software support. The research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013 Grant agreement N°320659).
Compliance with ethical standards
Conflict of interest disclosure
The authors declare no competing financial interest.
- 6.Gidden, J., Wyttenbach, T., Batka, J.J., Weis, P., Jackson, A.T., Scrivens, J.H., Bowers, M.T.: Poly(ethylene terephthalate) oligomers cationized by alkali ions: structures, energetics, and their effect on mass spectra and the matrix-assisted laser desorption/ionization process. J. Am. Soc. Mass Spectrom. 10, 883–895 (1999)CrossRefGoogle Scholar
- 14.Fernandez-Lima, F., Kaplan, D.A., Suetering, J., Park, M.A.: Gas-phase separation using a trapped ion mobility spectrometer. Int. J. Ion Mobil. Spectrom. 14, (2011)Google Scholar
- 21.Shvartsburg, A.A., Li, F., Tang, K., Smith, R.D.: Distortion of Ion structures by field asymmetric waveform ion mobility spectrometry. (2007)Google Scholar
- 29.Flanagan, J.M.: Mass spectrometry calibration using homogeneously substituted fluorinated triazatriphosphorines. US 5872357 A (1999)Google Scholar
- 30.De Winter, J., Lemaur, V., Ballivian, R., Chirot, F., Coulembier, O., Antoine, R., Lemoine, J., Cornil, J., Dubois, P., Dugourd, P., Gerbaux, P.: Size dependence of the folding of multiply charged sodium cationized polylactides revealed by ion mobility mass spectrometry and molecular modeling. Chem. A Eur. J. 17, 9738–9745 (2011)CrossRefGoogle Scholar
- 31.Lapthorn, C., Pullen, F., Chowdhry, B., Allen, M., Perkins, G., Dines, T., Mccullagh, M.: The effect of charge location in ion mobility mass spectrometry for small molecule analytes. 2009 (2012)Google Scholar