Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant

  • Scott M. Grayson
  • Brittany K. Myers
  • Jonas Bengtsson
  • Michael Malkoch
Research Article

Abstract

The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry.

Key words

Calibrant Dendrimer Calibration Polymer MALDI-TOF MS 

Supplementary material

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Copyright information

© American Society for Mass Spectrometry 2013

Authors and Affiliations

  • Scott M. Grayson
    • 1
  • Brittany K. Myers
    • 1
  • Jonas Bengtsson
    • 2
  • Michael Malkoch
    • 2
    • 3
  1. 1.Department of ChemistryTulane UniversityNew OrleansUSA
  2. 2.Polymer Factory Sweden ABStockholmSweden
  3. 3.Department of Fiber and Polymer Technology, School of Chemical Science and EngineeringKTH Royal Institute of TechnologyStockholmSweden

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