OmniSpect: An Open MATLAB-Based Tool for Visualization and Analysis of Matrix-Assisted Laser Desorption/Ionization and Desorption Electrospray Ionization Mass Spectrometry Images
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We present omniSpect, an open source web- and MATLAB-based software tool for both desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) that performs computationally intensive functions on a remote server. These functions include converting data from a variety of file formats into a common format easily manipulated in MATLAB, transforming time-series mass spectra into mass spectrometry images based on a probe spatial raster path, and multivariate analysis. OmniSpect provides an extensible suite of tools to meet the computational requirements needed for visualizing open and proprietary format MSI data.
Key wordsMass spectrometry imaging Desorption electrospray ionization (DESI) Matrix-assisted laser desorption ionization (MALDI) Data processing Multivariate image analysis Web-based tool Software MATLAB
The authors acknowledge support from ARRA NSF MRI Instrument Development grant no. 0923179 to FMF and MDW. This research was also supported by NIH grant U54CA119338, a Georgia Cancer Coalition Distinguished Cancer Scholar Award to Professor MDW, Hewlett Packard, and Microsoft Research.We would also like to thank Al Merrill, Cameron Sullards and Frank Chen for useful suggestions during the development of this software.
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