PLAGL1: an important player in diverse pathological processes
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The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses, but the molecular mechanisms by which the protein PLAGL1 participates in such diverse processes remains to be elucidated. In this review, we focus mainly on the molecular biology of PLAGL1 and the relevance of its abnormalities to several pathological processes.
KeywordsPLAGL1 Tumor suppressor gene Cancer Diabetes
We would like to thank Dr. Karen Meaburn and Dr. Tom Misteli for the critical reading of the manuscript.
Compliance with ethical standards
This study was funded by the National Council of Sciences and Technologies (CONICET); Argentine Agency for Science and Technology. Grant ANPCyT–FONCyT, PICT-2011-1897 to Luis A. Parada. The funders had no role in the preparation of the manuscript and the decision to publish.
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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