Journal of Applied Genetics

, Volume 58, Issue 1, pp 71–78 | Cite as

PLAGL1: an important player in diverse pathological processes

  • Ana F. Vega-Benedetti
  • Cinthia Saucedo
  • Patrizia Zavattari
  • Roberta Vanni
  • José L. Zugaza
  • Luis Antonio ParadaEmail author
Human Genetics • Review


The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses, but the molecular mechanisms by which the protein PLAGL1 participates in such diverse processes remains to be elucidated. In this review, we focus mainly on the molecular biology of PLAGL1 and the relevance of its abnormalities to several pathological processes.


PLAGL1 Tumor suppressor gene Cancer Diabetes 



We would like to thank Dr. Karen Meaburn and Dr. Tom Misteli for the critical reading of the manuscript.

Compliance with ethical standards


This study was funded by the National Council of Sciences and Technologies (CONICET); Argentine Agency for Science and Technology. Grant ANPCyT–FONCyT, PICT-2011-1897 to Luis A. Parada. The funders had no role in the preparation of the manuscript and the decision to publish.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2016

Authors and Affiliations

  • Ana F. Vega-Benedetti
    • 1
  • Cinthia Saucedo
    • 1
  • Patrizia Zavattari
    • 2
  • Roberta Vanni
    • 2
  • José L. Zugaza
    • 3
    • 4
    • 5
  • Luis Antonio Parada
    • 1
    Email author
  1. 1.Institute of Experimental Pathology, UNSa-CONICETSaltaArgentina
  2. 2.Biochemistry, Biology and Genetics Unit, Department of Biomedical SciencesUniversity of CagliariMonserratoItaly
  3. 3.IKERBASQUE, Basque Foundation for ScienceBilbaoSpain
  4. 4.Achucarro Basque Center for NeuroscienceZamudioSpain
  5. 5.Department of Genetics, Physic Anthropology and Animal Physiology, Faculty of Medicine and DentistryUniversity of the Basque CountryLeioaSpain

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