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PLAGL1: an important player in diverse pathological processes

  • Human Genetics • Review
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Abstract

The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses, but the molecular mechanisms by which the protein PLAGL1 participates in such diverse processes remains to be elucidated. In this review, we focus mainly on the molecular biology of PLAGL1 and the relevance of its abnormalities to several pathological processes.

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Acknowledgments

We would like to thank Dr. Karen Meaburn and Dr. Tom Misteli for the critical reading of the manuscript.

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Authors and Affiliations

  1. Institute of Experimental Pathology, UNSa-CONICET, Ave. Bolivia 5150, 4400, Salta, Argentina

    Ana F. Vega-Benedetti, Cinthia Saucedo & Luis Antonio Parada

  2. Biochemistry, Biology and Genetics Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato SP 8, Km 0.700, 09042, Monserrato, Cagliari, Italy

    Patrizia Zavattari & Roberta Vanni

  3. IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain

    José L. Zugaza

  4. Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, Building 205, Zamudio, Spain

    José L. Zugaza

  5. Department of Genetics, Physic Anthropology and Animal Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940, Leioa, Spain

    José L. Zugaza

Authors
  1. Ana F. Vega-Benedetti
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  2. Cinthia Saucedo
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  3. Patrizia Zavattari
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  4. Roberta Vanni
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  5. José L. Zugaza
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  6. Luis Antonio Parada
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Correspondence to Luis Antonio Parada.

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Funding

This study was funded by the National Council of Sciences and Technologies (CONICET); Argentine Agency for Science and Technology. Grant ANPCyT–FONCyT, PICT-2011-1897 to Luis A. Parada. The funders had no role in the preparation of the manuscript and the decision to publish.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Communicated by: Michal Witt

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Vega-Benedetti, A.F., Saucedo, C., Zavattari, P. et al. PLAGL1: an important player in diverse pathological processes. J Appl Genetics 58, 71–78 (2017). https://doi.org/10.1007/s13353-016-0355-4

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