Philosophy & Technology

, Volume 25, Issue 4, pp 495–512 | Cite as

Enhancing the Species: Genetic Engineering Technologies and Human Persistence

Special Issue

Abstract

Many of the existing ethical analyses of genetic engineering technologies (GET) focus on how they can be used to enhance individuals—to improve individual well-being, health and cognition. There is a gap in the current literature about the specific ways enhancement technologies could be used to improve our populations and species, viewed as a whole. In this paper, I explore how GET may be used to enhance the species through improvements in the gene pool. I argue one aspect of the species that may be desirable to enhance is ‘persistence’ or long-term viability. I then look at some of the ways in which GET could be used to improve human persistence and argue that the use of GET to secure benefits for individuals may compromise persistence. This suggests conflicts between uses of GET to enhance individuals and uses to promote the persistence of the species may occur. As GET are further developed, the likelihood that these conflicts will actually arise, and how we should resolve them if they do, will need to be considered.

Keywords

Genetic engineering Enhancement ethics Extinction ethics 

Notes

Acknowledgments

I would like to thank Michael Selgelid, Kim Sterelny, two anonymous reviewers for Philosophy and Technology and the editors of this special issue for comments on earlier versions of this paper.

References

  1. Agar, N. (2010). Humanity's end: why we should reject radical enhancement. Cambridge: A Bradford Book.Google Scholar
  2. Benatar, D. (2006). Better never to have been: the harm of coming into existence. New York: Oxford University Press.CrossRefGoogle Scholar
  3. Bostrom, N. (2002). Existential risks: analyzing human extinction scenarios and related hazards. Journal of Evolution and Technology, 9(1), 1–30.Google Scholar
  4. Brandon, R. (1990). Adaptation and environment. Princeton: Princeton University Press.Google Scholar
  5. Brown, C. (2011). Better never to have been believed: benatar on the harm of existence. Economics and Philosoph, 27, 45–52.CrossRefGoogle Scholar
  6. Carson, S., Peterson, J., & Higgins, D. (2003). Decreased latent inhibition is associated with increased creative achievement in high-functioning individuals. Journal of Personality and Social Psychology, 85, 499–506.CrossRefGoogle Scholar
  7. Chuang, J. H., & Li, H. (2004). Functional bias and spatial organization of genes in mutational hot and cold regions in the human genome. PLoS Biology, 2(2), E29.CrossRefGoogle Scholar
  8. Danchin, E., Charmantier, A., Champagne, F., Mesoudi, A., Pujol, B., & Blanchet, S. (2011). Beyond DNA: integrating inclusive inheritance into an extended theory of evolution. Nature Reviews Genetics, 12, 475–486.CrossRefGoogle Scholar
  9. DeGrazia, D. (2006). On the question of personhood beyond Homo sapiens. In P. Singerin (Ed.), Defence of animals: the second wave (pp. 40–53). New York: Blackwell.Google Scholar
  10. Dickey Zakaib, G. (2011) The peppered moth's dark genetic past revealed. Nature News. doi: 10.1038/news.2011.238
  11. Douglas, T. (2009). Moral enhancement. Journal of Applied Philosophy, 25, 228–245.CrossRefGoogle Scholar
  12. Frankham, R. (2005). Genetics and extinction. Biological Conservation, 126, 131–140.CrossRefGoogle Scholar
  13. Galvani, A., & Slatkin, M. (2003). Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele. Proceedings of the National Academy of Sciences, 100, 15276–15279.CrossRefGoogle Scholar
  14. Harman, E. (2009). Critical study—better never to have been: the harm of coming into existence. Noûs, 43, 776–785.CrossRefGoogle Scholar
  15. Harris, J. (2007). Enhancing evolution. Princeton: Princeton University Press.Google Scholar
  16. He, J., et al. (1997). CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature, 385, 645–649.CrossRefGoogle Scholar
  17. Ishii, K., Matsuda, H., Iwasa, Y., & Sasaki, A. (1989). Evolutionarily stable mutation rate in a periodically changing environment. Genetics, 121, 163–174.Google Scholar
  18. Jablonski, D. (2002). Survival without recovery after mass extinctions. Proceedings of the National Academy of Sciences of the United States of America, 99, 8139–8144.CrossRefGoogle Scholar
  19. Karlsson, E., & Lindblad-Toh, K. (2008). Leader of the pack: gene mapping in dogs and other model organisms. Nature Reviews Genetics, 9, 713–725.CrossRefGoogle Scholar
  20. Keri, S. (2009). Genes for psychosis and creativity: a promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement. Psychological Scienc, 20, 1070–1073.CrossRefGoogle Scholar
  21. Markett, J., et al. (2010). Population genetic diversity and fitness in multiple environments. BMC Evolutionary Biology, 10, 205.CrossRefGoogle Scholar
  22. Mayr, E. (1970). Populations, species, and evolution. Cambridge: Harvard University Press.Google Scholar
  23. Mill, J. (1906). Utilitarianism. Chicago: University of Chicago Press.Google Scholar
  24. Mitchell, M. (2009). Complexity: a guided tour. Oxford: Oxford University Press.Google Scholar
  25. Nemeth, C. J., & Nemeth-Brown, B. (2003). Better than individuals? The potential benefits of dissent and diversity for group creativity. In P. Paulus & B. Nijstad (Eds.), Group creativity. Oxford: Oxford University Press.Google Scholar
  26. Page, S. (2007). The difference: how the power of diversity creates better groups, firms, schools, and societies. Princeton: Princeton University Press.Google Scholar
  27. Parfit, D. (1987). Reasons and persons. Oxford: Oxford University Press.Google Scholar
  28. Pavot, W., Diener, E., & Fujita, F. (1990). Extraversion and happiness. Personality and Individual Differences, 12, 1299–1306.CrossRefGoogle Scholar
  29. Pepper, J., Brouwer, R., Boomsma, D., Kahn, R., & Hulshoff Pol, H. (2007). Genetic influences on human brain structure: a review of brain imaging studies in twins. Human Brain Mapping, 6, 464–473.CrossRefGoogle Scholar
  30. Persson, I., & Savulescu, J. (2011). Unfit for the future? Human nature, scientific progress, and the need for moral enhancement. In J. Savulescu, R. ter Meulen, & G. Kuhane (Eds.), Enhancing human capacities (pp. 486–500). New York: Blackwell.Google Scholar
  31. Powell, R. (2012). The evolutionary biological implications of human genetic engineering. Journal of Medicine and Philosophy, 37(3), 204–225.CrossRefGoogle Scholar
  32. Powell, R. (2012). The future of human evolution. British Journal for the Philosophy of Science, 63, 145–175.CrossRefGoogle Scholar
  33. Powell, R., & Buchanan, A. (2011). Breaking evolution's chains: the prospect of deliberate genetic modification in humans. The Journal of Medicine and Philosophy, 36, 6–27.CrossRefGoogle Scholar
  34. Rettew, D., Rebollo-Mesa, I., Hudziak, J., Willemsen, G., & Boomsma, D. (2008). Non-additive and additive genetic effects on extraversion. Behavioural Genetics, 38, 223–233.CrossRefGoogle Scholar
  35. Savulescu, J., & Kahane, G. (2009). The moral obligation to create children with the best chance of the best life. Bioethics, 23(5), 274–290.CrossRefGoogle Scholar
  36. Savulescu, J. (2006). Genetic interventions and the ethics of enhancement of human beings. In B. Steinbock (Ed.), The Oxford handbook of bioethics (pp. 516–533). Oxford: Oxford University Press.Google Scholar
  37. Savulescu, J., Sandberg, A., & Kahane, G. (2011). Well-being and enhancement. In J. Savulescu, R. ter Meulen, & G. Kuhane (Eds.), Enhancing human capacities (pp. 3–18). New York: Blackwell.Google Scholar
  38. Sidgwick, H. (1874). The methods of ethics. London: Macmillan.Google Scholar
  39. Singer, P. (1995). Rethinking life and death: the collapse of our traditional ethics. Oxford: Oxford University Press.Google Scholar
  40. Stahl, J., & Rammsayer, T. (2008). Extroversion-related differences in speed of premotor and motor processing as revealed by lateralized readiness potentials. Journal of Motor Behavior, 2, 143.CrossRefGoogle Scholar
  41. Starr, C., & Taggart, R. (2001). Evolution of life. Pacific Cove: Brooks/Cole.Google Scholar
  42. Sterelny, K. (2006). Folk logic and animal rationality. In S. Hurley & M. Nudds (Eds.), Rational animals? (pp. 293–312). Oxford: Oxford University Press.CrossRefGoogle Scholar
  43. Surowiecki, J. (2005). The wisdom of crowds. New York: Anchor.Google Scholar
  44. Wiley, E. O. (1978). The evolutionary species concept reconsidered. Systematic Biology, 27, 17–26.Google Scholar
  45. Wilkins, J. (2006). Species, kinds, and evolution. Reports of NCSE, 26, 36–45.Google Scholar
  46. Zeigler, P. (1969). The black death. London: Penguin.Google Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.School of Philosophy, Research School of Social SciencesAustralian National UniversityCanberraAustralia

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