Drug Delivery and Translational Research

, Volume 7, Issue 1, pp 89–99 | Cite as

Microwaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn wounds

  • Manisha Pandey
  • Najwa Mohamad
  • Wan-Li Low
  • Claire Martin
  • Mohd Cairul Iqbal Mohd Amin
Original Article
First Online:

Abstract

Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.

Keywords

Hydrogel microparticles Bacterial cellulose Cytotoxicity Partial-thickness burn wound Microwave irradiation 
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Notes

Acknowledgments

The authors would like to thank the Ministry of Higher Education, Malaysia (UKM-Farmasi-02-FRGS0192-2010) and the Universiti Kebangsaan Malaysia (INOVASI-2013-005) for their financial assistance and support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Controlled Release Society 2016

Authors and Affiliations

  • Manisha Pandey
    • 1
    • 2
  • Najwa Mohamad
    • 2
  • Wan-Li Low
    • 3
  • Claire Martin
    • 3
  • Mohd Cairul Iqbal Mohd Amin
    • 2
  1. 1.School of PharmacyInternational Medical UniversityKuala LumpurMalaysia
  2. 2.Centre for Drug Delivery Research, Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia
  3. 3.School of Pharmacy, Faculty of Science and EngineeringUniversity of WolverhamptonWolverhamptonUK

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