The best outcomes for going through pregnancy with diabetes—Clinical features of four recipients of the Lilly Insulin 50-Year Award—

  • Yasue OmoriEmail author
  • Keiko Yanagisawa
  • Asako Sato
Short Communication


The Lilly Insulin 50-Year Award of Japan has been held since 2003. This Award is presented to people with diabetes based on their efforts in injecting insulin for 50 years. Among the 23 recipients of this Award in 2018, four were recognized because of their excellent efforts in receiving continuous treatment for diabetes mellitus before, during and throughout their life after pregnancy. This report focuses on the clinical features of these recipients with successful delivery of newborns at Tokyo Women’s Medical University approximately 40–50 years ago. Three of the recipients [type 2 diabetes, n = 2 (cases 1 and 3); type 1 diabetes, n = 1 (case 4)] were treated before, during and after pregnancy, whereas one patient with type 2 diabetes (case 2) was only treated during pregnancy. Even though three recipients had a past history of stillbirth due to insufficient control of diabetes, all four recipients were directed to try to maintain normoglycemia before and during pregnancy, which resulted in the delivery of newborns without major events. The current ages of the recipients are 82, 78, 78 and 63 years old, respectively. No diabetic complications were observed in case 1. However, simple retinopathy occurred after ophthalmological treatment in case 3, and case 2 has received hemodialysis. Nevertheless, all of the patients have spent active lives with the confidence of successful delivery, even though none of the patient's HbA1c levels fell below 7% after delivery. The authors as their doctors are proud of the continuous efforts made by these four recipients to receive diabetes treatment before, during and after pregnancy. We therefore advocate “the best outcome for going through pregnancy with diabetes” to all diabetic patients who hope to become pregnant based on a planned pregnancy with the normalization of blood glucose.


Diabetic pregnancy Diabetic complications Non-obese 



Tokyo Women’s Medical University








estimated Glomerular Filtration Rate


Albumin Creatinine Ratio




European Association for the Study of Diabetes


Glycated Albumin


Compliance with ethical standards

Conflict of interest

None of the authors have any conflicts interest associated with this study.

Ethical standards

This study was carried out in accordance with the Declaration of Helsinki of 1964 and later versions and approved by the ethics committee of TWMU Hospital. Approval Number: 5145, Approval Date: 9 April 2019.

Informed consent

The four recipients gave their written informed consent to announce their results in the co-memorial book when they received Insulin 50-Year Award and we got the permission to be published their results with oral communication.


  1. 1.
    Uchigata Y, Otani T, Takaike H, Miura J, Osawa M, Tukahara S, Kasahara T, Iwamoto Y. Time-Course changes in clinical features of early-onset Japanese type 1 and type 2 diabetes: TWMU hospital-based study. Diabetes Res Clin Pract. 2008;82:80–6.CrossRefGoogle Scholar
  2. 2.
    Omori Y, Yanagisawa K, Sato A, Uchigata Y. The importance of nonstop treatment after delivery for pregnant women with type 2 diabetes. Diabetes Metab Res Rev. 2017;33:e2860.CrossRefGoogle Scholar
  3. 3.
    Omori Y, Yanagisawa K, Sato A. The excellent clinical features of seven recipients of The Lilly Insulin 50-Year Award who went through pregnancy with diabetes(medical message). Diabetes Pregnancy. 2019;19(1):1–6 (in Japanese).Google Scholar
  4. 4.
    Otani T, kasahara T, Uchigata Y. Profiles of 13 type 1 Lilly Insulin 50-Year Award winners at the Diabetes Center, Tokyo Women’s Medical University School of Medicine. J Japan Diab Soc. 2014;57(12):900–6.Google Scholar
  5. 5.
    Sun J, Keenan H, Cavallerano J, Asztalos B, Schaefer E, Sell D, Strauch C, Monnier V, Doria A, Aiello L, King G. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration, the Joslin 50-Year Medalist Study. Diabetes Care. 2011;34:968–74.CrossRefGoogle Scholar
  6. 6.
    DERI Mortality Study Group. International analysis of insulin-dependent diabetes mellitus mortality: a preventable mortality perspective. Am J Epidemiol. 1995;142:612–61.CrossRefGoogle Scholar
  7. 7.
    Schaefer U, Napoli A, Nolan CJ, The Diabetic Pregnancy Study Group. Diabetes in pregnancy; a new decade of challenges ahead. Diabetologia. 2018. Scholar

Copyright information

© The Japan Diabetes Society 2019

Authors and Affiliations

  1. 1.Diabetes CenterEbina General HospitalEbinaJapan
  2. 2.Department of Diabetology and MetabolismTokyo Women’s Medical University (TWMU)TokyoJapan
  3. 3.Department of Clinical LaboratoryTokyo Women’s Medical UniversityTokyoJapan

Personalised recommendations