Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988–2012: the Hisayama Study
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We estimated secular trends in the prevalence of type 2 diabetes (T2DM) and prediabetes, and examined potential explanatory factors for these trends in a Japanese community.
4 cross-sectional examinations were conducted among subjects aged 40–79 years in 1988 (n = 2,490), 2002 (n = 2,856), 2007 (n = 2,761), and 2012 (n = 2,644). Glucose tolerance status was defined by a 75g oral glucose tolerance test.
The age-standardized prevalence of T2DM increased significantly in both sexes from 1988 to 2002, and thereafter it remained stable in men, and decreased nonsignificantly in women from 2002 to 2012. The age-standardized prevalence of prediabetes in men increased significantly between 1988 and 2002, but then decreased significantly. A similar trend was observed in women. The age-specific prevalence of T2DM increased greatly in men aged 60–79 years and women aged 70–79 years from 1988 to 2002, and then plateaued at a high level, while a significant decreasing trend was observed in women aged 40–49 years. The mean values of body mass index (BMI) increased steeply in these elderly subjects from 1988 to 2002, and remained at a high level, whereas those in middle-aged women decreased appreciably over the study period.
Our findings suggest that in Japanese, there was no further increase in the prevalence of T2DM or prediabetes in either men or women in the 2000s. Secular change in the BMI level was likely to contribute to trends in the prevalence of T2DM, and thus the management of obesity may be important to reduce the prevalence of T2DM.
KeywordsType 2 diabetes Prediabetes Prevalence 75-g oral glucose tolerance test Community-based research
The authors thank the staff of the Division of Health and Welfare of Hisayama for their cooperation in this study. This study was supported in part by Grants-in-Aid for Scientific Research (A) (JP16H02644, and JP16H02692) ,(B) (JP16H05850, JP16H05557, JP17H04126, and JP18H02737) and (C) (JP16K09244, JP17K09114, JP17K09113, JP17K01853, JP18K07565, and JP18K09412) and (Early-Career Scientists) (JP18K17925, and JP18K17382) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; by Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan (H29-Junkankitou-Ippan-003, and H30-Shokuhin-[Sitei]-005); and by the Japan Agency for Medical Research and Development (JP18dk0207025, JP18ek0210082, JP18gm0610007, JP18ek0210083, JP18km0405202, JP18ek0210080, JP18fk0108075).
Compliance with ethical standards
Conflict of interest
The authors declare that there is no conflict of interest associated with this manuscript.
Human rights statement
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (the Kyushu University Institutional Review Board for Clinical Research, date of approval: 28 July 2017, approval no. 29-213) and with the Helsinki Declaration of 1964 and later versions.
Informed consent was obtained from the participants before they were included in the study.
- 9.Kabeya Y, Kato M, Isogawa A, Takahashi Y, Matsushita Y, Goto A, Iso H, Inoue M, Mizoue T, Tsugane S, Kadowaki T, Noda M. Descriptive epidemiology of diabetes prevalence and HbA1c distributions based on a self-reported questionnaire and a health checkup in the JPHC diabetes study. J Epidemiol. 2014;24:460–8.CrossRefPubMedGoogle Scholar
- 10.Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y. Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study. J Diabetes Investig. 2014;5:162–9.CrossRefPubMedGoogle Scholar
- 11.Koo BK, Kim EK, Choi H, Park KS, Moon MK. Decreasing trends of the prevalence of diabetes and obesity in Korean women aged 30–59 years over the past decade: results from the Korean National Health and Nutrition Examination Survey, 2001–2010. Diabetes Care. 2013;36:e95–6.CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y. Secular trends in cardiovascular disease and its risk factors in Japanese: half century data from the Hisayama Study, 1961-2009. Circulation. 2013;128:1198–205.CrossRefPubMedGoogle Scholar
- 17.Committee on the standardization of diabetes mellitus-related laboratory testing of Japan Diabetes Society. International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Investig. 2012;3:39–40.CrossRefPubMedCentralGoogle Scholar
- 20.Ministry of Health, Labour and Welfare. The National Health and Nutrition Survey in Japan, 2012. 2014 (in Japanese).Google Scholar
- 21.Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M. Age standardization of rates: a new WHO standard. Geneva: World Health Organization; 2001.Google Scholar
- 26.Sadikot SM, Nigam A, Das S, Bajaj S, Zargar AH, Prasannakumar KM, Sosale A, Munichoodappa C, Seshiah V, Singh SK, Jamal A, Sai K, Sadasivrao Y, Murthy SS, Hazra DK, Jain S, Mukherjee S, Bandyopadhay S, Sinha NK, Mishra R, Dora M, Jena B, Patra P, Goenka K. The burden of diabetes and impaired glucose tolerance in India using the WHO 1999 criteria: prevalence of diabetes in India study (PODIS). Diabetes Res Clin Pract. 2004;66:301–7.CrossRefPubMedGoogle Scholar
- 29.Pani LN, Korenda L, Meigs JB, Driver C, Chamany S, Fox CS, Sullivan L, D’Agostino RB, Nathan DM. Effect of aging on A1C levels in individuals without diabetes: evidence from the Framingham Offspring Study and the National Health and Nutrition Examination Survey 2001-2004. Diabetes Care. 2008;31:1991–6.CrossRefPubMedPubMedCentralGoogle Scholar