Effect of deglutition aids on the inhibitory effect of orally disintegrating tablets of voglibose on the postprandial elevation of blood glucose levels: a case investigating the interaction between xanthan gum and voglibose
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In this study, we first performed a disintegration test of the voglibose orally disintegrating (V-OD) tablet immersed in jelly-wafer (JW, V-ODims/jw) for 10 min and compared it with the disintegration time of V-OD that was not immersed in JW. We then orally administered the V-ODims/jw tablet to 7 healthy adults and compared the shift in blood glucose levels (BGLs), after loading with a sucrose solution (Suc-sol, 100 g/150 mL), with that after administration of the non-immersed V-OD tablet. The disintegration time of V-ODims/jw tablet was shorter than that of V-OD. When administered to healthy adults, the BGL after loading with Suc-sol was higher with V-ODims/jw tablet administration than with V-OD tablet. We predict that the expression of the efficacy of voglibose is reduced as a result of the interaction between voglibose and the polysaccharide, xanthan gum (XG), since it is a common additive in JW. This study shows that deglutition aids with additives that do not affect pharmacokinetics must be carefully selected for administering along with pharmaceuticals, because of a suggested possibility that the interaction between these pharmaceuticals and the additives in the deglutition aids weaken the drug efficacy. A more careful selection of deglutition aids from the wide selection of medication is especially important when administered to patients who use these deglutition aids often, such as elderly individuals or individuals with a deglutition disorder.
KeywordsXanthan gum Jelly-wafer Voglibose Orally disintegrating tablet Blood glucose elevation
Area under the incremental concentration–time curve
Blood glucose levels
The Japanese Pharmacopoeia, 17th edition
Voglibose orally disintegrating tablet
Voglibose orally disintegrating tablet immersed in food thickener
Voglibose orally disintegrating tablet immersed in jelly-wafer
Compliance with ethical standards
Conflict of interest
None of the authors have any conflicts of interest associated with this study.
This study was carried out in accordance with the Declaration of Helsinki of 1964 and later versions and approved by the ethics committee of Hospital BANDO (approval number: not applicable, approval date: 8 March 2017).
The healthy Japanese adult males gave their written informed consent to participate in this study and its results to be published.
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