Diabetology International

, Volume 3, Issue 4, pp 197–201

Prediction of near-future HbA1c levels using glycated albumin levels before and after glimepiride administration for 2 weeks is useful to determine the effectiveness of the treatment

  • Masafumi Koga
  • Jun Murai
  • Hiroshi Saito
  • Soji Kasayama
Original article

DOI: 10.1007/s13340-012-0075-x

Cite this article as:
Koga, M., Murai, J., Saito, H. et al. Diabetol Int (2012) 3: 197. doi:10.1007/s13340-012-0075-x

Abstract

Aims

We previously reported an equation predicting near-future HbA1c levels using glycated albumin (GA) levels before and after treatment for diabetes. In this study, we investigated whether the prediction of HbA1c levels is useful to decide on the necessity of additional treatment for diabetes.

Method

This study consisted of 11 patients with type 2 diabetes with HbA1c levels ≥8.4 % without any medical treatment. Glimepiride administration was started at a dose of 1 mg/day, and the HbA1c level at 14 weeks was predicted by GA levels before and 2 weeks after the administration. When the predicted HbA1c level at 14 weeks was <8.0 %, the treatment was continued. Otherwise, the dose of glimepiride was raised or metformin was added.

Results

In seven patients whose treatment was unchanged, the predicted HbA1c level at 14 weeks was 7.1 ± 0.5 %, which was similar to the measured HbA1c level at 14 weeks (7.1 ± 0.6 %). In four patients who were given additional treatment, the predicted HbA1c level at 14 weeks was 9.4 ± 1.0 %, significantly higher than the measured HbA1c at 14 weeks (7.5 ± 0.7 %).

Conclusion

The prediction of near-future HbA1c levels using GA facilitates an early decision on the necessity of additional treatment for diabetes.

Keywords

Glycated albumin HbA1c Glimepiride Type 2 diabetes 

Copyright information

© The Japan Diabetes Society 2012

Authors and Affiliations

  • Masafumi Koga
    • 1
  • Jun Murai
    • 1
  • Hiroshi Saito
    • 1
  • Soji Kasayama
    • 2
  1. 1.Department of Internal MedicineKinki Central HospitalItamiJapan
  2. 2.Department of MedicineNissay HospitalOsakaJapan

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