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Indian Journal of Virology

, Volume 24, Issue 3, pp 373–379 | Cite as

Comparative immunogenicity of two peste des petitis ruminants (PPR) vaccines in South Indian sheep and goats under field conditions

  • A. K. Santhosh
  • Amitha R. Gomes
  • Raveendra Hegde
  • D. Rathnamma
  • B. M. Veeregowda
  • S. M. Byregowda
  • C. Renukaprasad
  • V. Bhanuprakash
  • K. Prabhudas
  • Nagendra R. HegdeEmail author
  • Shrikrishna Isloor
Original Article

Abstract

Peste des petitis ruminants (PPR) is an economically important endemic viral disease of sheep and goats in India, where several different homologous PPR vaccine candidates have been developed. We evaluated the serological response to two vaccine strains, Arasur/87 and Sungri/96, in South Indian cross-bred and native sheep and goats reared under organized and unorganized settings. Animals seronegative (percent inhibition or PI <40) by competitive enzyme-linked immunosorbent assay (c-ELISA) were immunized with either of the vaccine strains or placebo. Sera collected on 21, 60 and 90 days post-vaccination were subjected to c-ELISA and serum neutralization test (SNT). Seropositivity (PI >40), seroconversion (fourfold increase in SNT titres) and seroprotection (SNT titre of ≥8 deemed to be protective) ranged from 66.7 to 84.0 %, 56.0 to 69.2 %, and 60.0 to 76.0 %, respectively. However, no significant difference was observed between responses to the two vaccine strains. These results support the premise that the two vaccine strains are equally efficacious.

Keywords

Peste des petitis ruminants Homologous vaccine Comparative evaluation Humoral immune response Field testing 

Notes

Acknowledgments

We thank Dr. D. Muthuchelvan, Indian Veterinary Research Institute, and Dr. V. Balamurugan, Project Directorate on Animal Disease Monitoring and Surveillance, Indian Council of Agricultural Research, for valuable inputs.

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Copyright information

© Indian Virological Society 2013

Authors and Affiliations

  • A. K. Santhosh
    • 1
  • Amitha R. Gomes
    • 2
  • Raveendra Hegde
    • 2
  • D. Rathnamma
    • 1
  • B. M. Veeregowda
    • 1
  • S. M. Byregowda
    • 2
  • C. Renukaprasad
    • 2
    • 5
  • V. Bhanuprakash
    • 6
  • K. Prabhudas
    • 3
  • Nagendra R. Hegde
    • 4
    Email author
  • Shrikrishna Isloor
    • 1
  1. 1.Department of Veterinary MicrobiologyKarnataka Veterinary, Animal and Fisheries Sciences UniversityBengaluruIndia
  2. 2.Institute of Animal Health and Veterinary BiologicalsBengaluruIndia
  3. 3.Project Directorate on Animal Disease Monitoring and SurveillanceBengaluruIndia
  4. 4.Ella FoundationGenome ValleyHyderabadIndia
  5. 5.Karnataka Veterinary, Animal and Fisheries Sciences UniversityBidarIndia
  6. 6.Indian Veterinary Research InstituteBengaluruIndia

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