Autoimmunity Highlights

, Volume 4, Issue 3, pp 87–94

Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis

  • Periklis Vounotrypidis
  • Georgios Kouklakis
  • Konstantinos Anagnostopoulos
  • Petros Zezos
  • Alexandros Polychronidis
  • Efstratios Maltezos
  • Eleni Efremidou
  • Michael Pitiakoudis
  • Nikolaos Lyratzopoulos
Original Article
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Abstract

Purpose

This study aims to investigate any associations of the proinflammatory cytokine IL-1 in treated patients with inflammatory bowel disease (IBD) and the enteropathic seronegative spondylarthritis (eSpA).

Methods

Thirty-four patients with Crohn’s disease (CD), 26 with ulcerative colitis (UC) and 14 patients with SpA participated in the study. Valid clinical indexes, CRP values and the endoscopic and histologic examination were used for the determination of disease activity. IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra) were measured by ELISA. Nonparametric tests were used for continuous and categorical data.

Results

Enteropathic SpA diagnosed in 29.4 % CD and 30.8 % UC patients. Active disease had 58.8 % CD (aCD), 76.9 % UC and 50 % SpA patients. Active and inactive CD (iCD) significantly differ on IL-1α levels (11.2 vs. 3.9 pg/ml; p = 0.034). Active and inactive UC significantly differ on IL-1β (3.7 vs. 2.3 pg/ml; p = 0.054) and IL-1Ra levels (15.9 vs. 12.7 pg/ml; p = 0.023). Active and inactive SpA (iSpA) significantly differ on IL-1Ra (16.9 vs. 14.8 pg/ml; p = 0.033) and marginally on IL-1α levels (20 vs. 3.9 pg/ml; p = 0.06). Patients with aCD/ieSpA exhibited significant differences on IL-1α (p = 0.022) compared to those with iCD/ieSpA.

Conclusions

IL-1α is associated with CD activity, while IL-1β and IL-1Ra are associated with UC activity in treated patients with IBD. Prominent cytokine in SpAs seems to be IL-1α.

Keywords

Crohn’s disease Ulcerative colitis Cytokines Extra-intestinal manifestations 

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Periklis Vounotrypidis
    • 1
  • Georgios Kouklakis
    • 1
  • Konstantinos Anagnostopoulos
    • 2
  • Petros Zezos
    • 1
  • Alexandros Polychronidis
    • 1
  • Efstratios Maltezos
    • 3
  • Eleni Efremidou
    • 1
  • Michael Pitiakoudis
    • 1
  • Nikolaos Lyratzopoulos
    • 1
  1. 1.Department of Inflammatory Bowel DiseasesUniversity Hospital of Alexandroupolis, Democritus University of ThraceDragana, AlexandroupolisGreece
  2. 2.Department of Medicine, Laboratory of BiochemistryDemocritus University of ThraceDragana, AlexandroupolisGreece
  3. 3.Department of Internal MedicineUniversity Hospital of Alexandroupolis, Democritus University of ThraceDragana, AlexandroupolisGreece

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