Hepatitis C virus and autoimmunity
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- Böckle, B.C. & Sepp, N.T. Autoimmun Highlights (2010) 1: 23. doi:10.1007/s13317-010-0005-5
Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to systemic autoimmune disorders. In this review we categorize these diseases into three groups according to the main pathogenetic process involved, in particular B-cell-mediated, T-cell-mediated and complex autoimmune systemic diseases.
KeywordsHepatitis C Extrahepatic manifestations Autoimmune mechanism Mixed cryoglobulinaemia vasculitis Lymphoma
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