Indian Pediatrics

, Volume 56, Issue 10, pp 868–872 | Cite as

Severe Pulmonary Arteriopathy in a Neonate with Congenital Rubella Syndrome and Patent Ductus Arteriosus

  • Supreet Khurana
  • Akriti Bansal
  • Shiv Sajan SainiEmail author
  • Anand Mishra
  • Praveen Kumar
Clinicopathological Conference


Neonates with congenital rubella syndrome (CRS) are known to have associated congenital cardiac malformations. Patent ductus arteriosus (PDA) is one the most common cardiac anomalies associated with CRS. PDA refractory to medical management and associated with ventilatory dependence is considered for surgical ligation. However, the management of PDA can be challenging in the presence of underlying lung disease or pulmonary vascular disease. Outcomes after closure in neonates are dependent upon age, weight, nutritional status, pre-operative pulmonary arterial hypertension and presence of chronic lung disease. We present a neonate with CRS who required surgical PDA closure. The neonate developed severe pulmonary arterial hypertension which led to fatal outcome. The clinical course is corroborated with histo-pathological changes observed on the autopsy of this neonate.


Complications Epidemiology German measles Pregnancy 


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Prof Ashim Das for conducting autopsy, providing us with essential information regarding histopathological findings and modification and approval of pathology protocol.

Funding: None; Competing interest: None stated.


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Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  • Supreet Khurana
    • 1
  • Akriti Bansal
    • 2
  • Shiv Sajan Saini
    • 1
    Email author
  • Anand Mishra
    • 3
  • Praveen Kumar
    • 1
  1. 1.Division of Neonatology, Department of PediatricsPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of PathologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of Cardiothoracic Vascular SurgeryPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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