Comparison of Soybean-based Oil and MCT-olive-fish-soy Oil Intravenous Lipid Emulsions on Soluble Adhesion Markers in Preterm Neonates with Sepsis: A Randomized Controlled Trial
- 13 Downloads
To compare the effects of two different intravenous lipid emulsions on soluble adhesion markers in preterm infants with sepsis.
This randomized controlled pilot trial was conducted from February 2016 to February 2017. 40 preterm infants with sepsis were enrolled and assigned to receive either Medium chain triglyceride-Olive-Fish-Soy lipid emulsion (MOFS-LE) or soybean oil-based lipid emulsion (S-LE). Outcomes of the study were changes in sICAM-1 and leukocyte integrin β2 levels, and growth after 7 days of intervention.
Leukocyte integrin β2 was significantly higher in MOFS-LE group. No statistically significant differences were observed for sICAM-1, duration of mechanical ventilation and antibiotics treatment, and mortality rate.
Leukocyte integrin β2 was significantly higher in preterm septic neonates who received MOFS-LE.
KeywordsParenteral nutrition Polyunsaturated fatty acids Soluble adhesion molecules
Trial registrationClinicalTrials.gov (NCT03275090)
Unable to display preview. Download preview PDF.
Funding: None; Competing Interest: None stated.
- 3.Kapoor V, Glover R, Malviya MN. Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants. Cochrane Database Syst Rev. 2015;12:CD009172.Google Scholar
- 8.Edgar JDM, Gabriel V, Gallimore JR, McMillan SA, Grant J. A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection. BMC Pediatr. 2010;10:22.CrossRefGoogle Scholar
- 11.Uthaya SN, Liu X, Babalis D, Doré CJ, Warwick J, Bell J, et al. Nutritional evaluation and optimisation in neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: A randomised double-blind controlled trial. Effic Mech Eval. 2016;3.CrossRefGoogle Scholar