What is New in Management of Pediatric Tuberculosis ?
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Tuberculosis continues to haunt mankind since its discovery more than a century ago. Although commendable advancements have been made in the diagnosis as well as treatment, especially in the last couple of decades, the healthcare burden of this disease worldwide is immense. Continuously evolving medical science has provided recent changes in national guidelines along with discovery of newer antitubercular drugs after many decades. In view of WHO declaring tuberculosis as a global health emergency and strong commitment being reflected by Government of India whereby National Strategic Plan aims to eliminate tuberculosis by 2025, it is high time that we work collectively on the goal of tuberculosis elimination. This article sums up the updates on newer anti-tubercular drugs as well as the recent changes adopted in Revised National Tuberculosis Control Program.
KeywordsAnti-tubercular drugs Mycobacterium tuberculosis Treatment
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- 1.World Health Organization: Global tuberculosis report 2016. Available from: Error! Hyperlink reference not valid.www.who.int/tb/publications/global_report/en/. Accessed June 2, 2017.Google Scholar
- 2.TB India 2016: Revised National Tuberculosis Control Programme 2016, Annual Status Report. Available from: http://www. tbcindia.nic.in Accessed June 2, 2017.Google Scholar
- 5.Working group on new TB Drugs. Clinical Pipe line. Available from: http://www.newtbdrugs.org/pipeline/clinical /. Accessed December 25, 2017.Google Scholar
- 6.Lienhardt C, Vernon A, Raviglione MC. New drugs and new regimens for the treatment of tuberculosis: review of the drug development pipeline and implications for national programmes. Curr Opin Pulm Med. 2010;16:186–93.Google Scholar
- 8.Peloquin CA, Velasquez GE, Lecca L, Calderon RI, Coit J, Milstein M, et al. Pharmacokinetic evidence from the HIRIF trial to support increased doses of rifampin for tuberculosis. Antimicrob Agents Chemother. 2017;25;61. pii:e00038–17.Google Scholar
- 16.Mohan A, Kumar DP, Harikrishna J. Newer anti–TB drugs and drug delivery systems. Medicine update. New Delhi: Jaypee Brothers Medical Publishers (for The Association of Physicians of India). 2013:388–92.Google Scholar
- 19.Zhang X, Falagas ME, Vardakas KZ, Wang R, Qin R, Wang J, et al. Systematic review and meta–analysis of the efficacy and safety of therapy with linezolid containing regimens in the treatment of multidrug–resistant and extensively drug–resistant tuberculosis. J Thorac Dis. 2015;7:603–15.Google Scholar
- 20.D’Ambrosio L, Centis R, Sotgiu G, Pontali E, Spanevello A, Migliori GB. New anti–tuberculosis drugs and regimens: 2015 update. ERJ Open Res. 2015;1:00010–2015.Google Scholar
- 22.Dooley KE, Obuku EA, Durakovic N, Belitsky V, Mitnick C, Nuermberger EL, and on behalf of the Efficacy Subgroup, RESIST–TB. World Health Organization group 5 drugs for the treatment of drug–resistant tuberculosis: unclear efficacy or untapped potential? J Infect Dis. 2013;207:1352–8.CrossRefGoogle Scholar
- 23.World Health Organization. The use of bedaquiline in the treatment of multidrug–resistant tuberculosis: interim policy guidance. WHO; 2013. Available from: http://www.who.int/en/. Accessed September 6, 2017.Google Scholar
- 24.Guidelines for use of bedaquiline in RNTCP PMDT India. Available from: http://www.tbcindia.nic.in. Accessed August 30, 2017.Google Scholar
- 26.Pontali E, D’Ambrosio L, Centis R, Sotgiu G, Migliori GB. Multidrug–resistant tuberculosis and beyond: an updated analysis of the current evidence on bedaquiline. Eur Respir J. 2017;22;49.Google Scholar
- 29.World Health Organization. The Use of Delamanid in the Treatment of Multidrug–Resistant Tuberculosis: Interim Policy Guidance. WHO; 2013. Available from http://www.who.int/en/. Accessed September 6, 2017.Google Scholar
- 31.World Health Organization: The use of delamanid in the treatment of multidrug–resistant tuberculosis in children and adolescents: interim policy guidance. World Health Organization; 2016. Available from: http://www.who.int/en/. Accessed April 15, 2018.Google Scholar
- 34.Arora S. Eradication of Mycobacterium Tuberculosis in 2 months with LL3858: a preclinical study. Int J Tubercl Lung Dis. 2004;8:S29.Google Scholar
- 37.Revised National TB Control Programme: Technical and Operational Guideline for Tuberculosis Control in India 2016. Available from: http://www.tbcindia.gov.in. Accessed April 10, 2018.Google Scholar
- 41.Lienhardt C, Vernon A, Raviglione MC. New drugs and new regimens for the treatment of tuberculosis: review of the drug development pipeline and implications for national programmes. Curr Opin Pulm Med. 2010;16:186–93.Google Scholar