Indian Pediatrics

, Volume 56, Issue 1, pp 67–68 | Cite as

Congenital B-cell Acute Lymphoblastic Leukemia with Congenital Rubella Infection

  • Dhan Raj BagriEmail author
  • Krapal Singh Yadav
  • Rambabu Sharma
  • Sandhya Gulati
Case Report



Congenital B-cell Acute lymphoblastic leukemia (ALL) is a rare malignancy.

Case Characteristics

A newborn infant presented with purpuric spots and ecchymotic patches, blueberry muffin rash, depressed neonatal reflexes, respiratory distress and hepatosplenomegaly. Peripheral smear revealed atypical blast cells. Serum ELISA was positive for Rubella IgM and IgG antibodies. Flow cytometry suggested congenital B-cell ALL.


The baby died after 3 days due to suspected intracranial hemorrhage.


Congenital leukemia may be rarely associated with congenital rubella infection.


Acute leukemia MMR vaccine Rubella virus 


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Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  • Dhan Raj Bagri
    • 1
    • 3
    Email author
  • Krapal Singh Yadav
    • 1
  • Rambabu Sharma
    • 1
  • Sandhya Gulati
    • 2
  1. 1.Department of Pediatrics, Sir Padampat Mother and Child Health Institute, JK Lon HospitalSMS Medical CollegeJaipurIndia
  2. 2.Department of Pathology, Sir Padampat Mother and Child Health Institute, JK Lon HospitalSMS Medical CollegeJaipurIndia
  3. 3.Departments of PediatricsSMS Medical CollegeJaipurIndia

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