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Indian Pediatrics

, Volume 55, Issue 12, pp 1062–1065 | Cite as

Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis

  • Isha Saini
  • Aparna Mukherjee
  • Hitender Gautam
  • Mohit Singla
  • Kr Jat
  • Rakesh Lodha
  • Urvashi B Singh
  • Sk Kabra
Research Paper
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Abstract

Objective

To evaluate utility of Xpert MTB/RIF in bronchoalveolar lavage fluid in children with probable pulmonary tuberculosis.

Methods

Children with probable pulmonary tuberculosis with negative smear and Xpert on induced sputum/gastric aspirate were subjected to bronchoalveolar lavage (BAL) for Xpert assay and mycobacterial liquid culture. Data of children <14 y undergoing bronchoscopy for suspected MDR-TB (n=12) were also analyzed. The sensitivity of Xpert in BAL fluid for diagnosis of probable and confirmed pulmonary tuberculosis was calculated with clinico-radiological diagnosis and culture as gold standards, respectively.

Results

Of 41 enrolled children, 24 (58.5%) had Xpert positive in BAL fluid and 11 (26.8%) had culture confirmed tuberculosis (BAL fluid;10; sputum,1). The sensitivity of Xpert in BAL fluid among probable and culture confirmed tuberculosis cases was 58.5% (24/41) and 81.8% (9/11), respectively.

Conclusion

Xpert in bronchoalveolar lavage fluid has good sensitivity in both probable and confirmed pulmonary tuberculosis in children.

Keywords

Bronchoscopy CBNAAT Pediatric TB 

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Copyright information

© Indian Academy of Pediatrics 2018

Authors and Affiliations

  • Isha Saini
    • 1
  • Aparna Mukherjee
    • 1
  • Hitender Gautam
    • 2
  • Mohit Singla
    • 1
  • Kr Jat
    • 1
  • Rakesh Lodha
    • 1
  • Urvashi B Singh
    • 2
  • Sk Kabra
    • 1
  1. 1.Departments of PediatricsAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Departments of MicrobiologyAll India Institute of Medical SciencesNew DelhiIndia

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