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Indian Pediatrics

, Volume 55, Issue 11, pp 951–956 | Cite as

Supplementation with Three Different Daily Doses of Vitamin D3 in Healthy Pre-pubertal School Girls: A Cluster Randomized Trial

  • Raman Kumar Marwaha
  • A Mithal
  • Neetu Bhari
  • G Sethuraman
  • Sushil Gupta
  • Manoj Shukla
  • Archana Narang
  • Aditi Chadda
  • Nandita Gupta
  • V Sreenivas
  • Ma Ganie
Research Paper

Abstract

Objective

To compare the adequacy and efficacy of different doses of vitamin D3 in pre-pubertal girls.

Design

Cluster Randomized controlled trial.

Setting

Public school in Delhi, India, between August 2015 and February 2016.

Participants

216 healthy pre-pubertal girls, aged 6.1-11.8 years.

Intervention

Daily supplementation with 600 IU (n=74), 1000 IU (n=67) or 2000 IU (n=75) of vitamin D3 under supervision for 6 months.

Outcome measures

Primary: Rise in serum 25 hydroxy Vitamin D (25(OH)D); Secondary: Change in bone formation and resorption markers.

Results

Following 6 months of supplementation, the mean (SD) rise in serum 25(OH)D was maximum with 2000 IU (24.09 (8.28) ng/mL), followed by with 1000 IU (17.96 (6.55) ng/mL) and 600 IU (15.48 (7.00) ng/mL). Serum 25(OH)D levels of ≥20 ng/mL were seen in 91% in 600 IU group, 97% in 1000 IU group and 100% in 2000 IU group. The overall mean (SD) rise in urinary calcium creatinine ratio (0.05 (0.28) to 0.13 (0.12) mg/mg), and serum procollagen type I N-terminal propeptide (538.9 (199.78) to 655.5 (218.24) ng/mL), and reduction in serum carboxy-terminal telopeptide (0.745 (0.23) to 0.382 (0.23) ng/mL) was significant (P<0.01). The change in the above parameters was comparable among the three groups after adjustment for age.

Conclusion

Daily vitamin D supplementation with 600 IU to 2000 IU for 6 months results in Vitamin D sufficiency in >90% of prepubertal girls.

Keywords

Micronutrient supplementation Prevention Vitamin D deficiency 

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Copyright information

© Indian Academy of Pediatrics 2018

Authors and Affiliations

  • Raman Kumar Marwaha
    • 1
  • A Mithal
    • 2
  • Neetu Bhari
    • 3
  • G Sethuraman
    • 3
  • Sushil Gupta
    • 4
  • Manoj Shukla
    • 4
  • Archana Narang
    • 5
  • Aditi Chadda
    • 5
  • Nandita Gupta
    • 6
  • V Sreenivas
    • 7
  • Ma Ganie
    • 6
  1. 1.International Life Sciences Institute (India)New DelhiIndia
  2. 2.Medanta Hospital GurgaonHaryanaIndia
  3. 3.Departments of DermatologyAIIMSNew DelhiIndia
  4. 4.SGPGI, Lucknow, Uttar PradeshNew DelhiIndia
  5. 5.Dr BR Sur Homeopathic Medical CollegeNew DelhiIndia
  6. 6.Departments of EndocrinologyAIIMSNew DelhiIndia
  7. 7.Departments of BiostatisticsAIIMSNew DelhiIndia

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