Indian Pediatrics

, Volume 52, Issue 4, pp 303–306 | Cite as

Blood lead levels and childhood asthma

  • Ahmed Abdullah Mohammed
  • Faisal Yosef Mohamed
  • El-Sayed El-Okda
  • Adel Besheer Ahmed
Research Paper

Abstract

Objectives

To measure blood lead levels in children (5–14 y) with bronchial asthma, and correlate with asthma severity.

Design

Cross-sectional analytical.

Setting

Pediatric Allergy and Immunology Clinic of a Children’s hospital in Cairo, Egypt.

Participants

200 children (127 males) with bronchial asthma and125 age- and sex-matched healthy controls (80 males).

Procedure

Blood lead levels were measured by atomic absorption spectrophotometer technique, and were subsequently correlated with asthma severity.

Results

No significant difference in mean (SD) blood lead levels was observed between children with asthma [13.3 (4.8) μg/dL] and control group [11.4 (3.9) μg/dL]. 190 children (58.5%) had elevated blood lead levels (>10 μg/dL), with no significant difference between patients (60%) and controls (56%). Patients with elevated blood lead levels had significantly higher frequency of eosinophilia (66.7%) and increased total immunoglobulin E (83.3%) compared to other patients with blood lead levels <10 ìg/ dL (10% and 43.8%, respectively). Patients of asthma with elevated blood lead levels had higher grades of severity of asthma compared to those with blood lead levels <10 μg/dL.

Conclusions

Blood lead levels are not significantly associated with diagnosis of asthma but elevated blood lead levels seem to be associated with increased asthma severity and higher frequency of eosinophilia and elevated immunoglobulin E levels.

Keywords

Bronchial asthma Eosinophilia Lead poisoning Risk factors. 

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Copyright information

© Indian Academy of Pediatrics 2015

Authors and Affiliations

  • Ahmed Abdullah Mohammed
    • 1
  • Faisal Yosef Mohamed
    • 1
  • El-Sayed El-Okda
    • 2
  • Adel Besheer Ahmed
    • 1
  1. 1.Departments of Pediatrics, Faculty of MedicineAin Shams UniversityCairoEgypt
  2. 2.Departments of Community medicine, Faculty of MedicineAin Shams UniversityCairoEgypt

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