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Indian Pediatrics

, Volume 50, Issue 10, pp 929–933 | Cite as

Efficacy of fixed low dose hydroxyurea in Indian children with sickle cell anemia: A single centre experience

  • Dipti L. JainEmail author
  • Mohini Apte
  • Roshan Colah
  • Vijaya Sarathi
  • Saumil Desai
  • Amruta Gokhale
  • Amol Bhandarwar
  • Harshwardhan L. Jain
  • Kanjaksha Ghosh
Research Paper

Abstract

Introduction

Data on the efficacy of hydroxyurea (HU) in Indian children with sickle cell anaemia (SCA) is limited. Hence, we have evaluated the efficacy of fixed low dose HU in Indian children.

Methods

The study cohort consisted of 144 children (<18 years of age) with SCA having severe manifestations (≥3 episodes of vasocclusive crisis or blood transfusions, or having ≥1 episode of acute chest syndrome or cerebrovascular stroke or sequestration crisis) who were started on fixed low dose HU (10 mg/kg/day). They were followed up for two years and monitored for the hematological and clinical efficacy and safety.

Results

There was significant increase in the fetal hemoglobin level (HbF%), total hemoglobin and mean corpuscular volume. Vasoocclusive crises, blood transfusions, acute chest syndrome, sequestration crises and hospitalizations decreased significantly. Baseline HbF% had significant positive correlation with HbF% at 24 months. There was significant negative correlation between baseline HbF% and change in HbF% from baseline to 24 months. No significant correlation was found between HbF% at baseline and clinical event rates per year after HU. No major adverse events occurred during the study period.

Conclusion

Fixed low dose HU is effective and safe in Indian children with SCA.

Keywords

Child Hydroxyurea India Low dose Sickle Cell disease 

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Copyright information

© Indian Academy of Pediatrics 2013

Authors and Affiliations

  • Dipti L. Jain
    • 1
    • 3
    Email author
  • Mohini Apte
    • 1
  • Roshan Colah
    • 2
  • Vijaya Sarathi
    • 1
  • Saumil Desai
    • 1
  • Amruta Gokhale
    • 1
  • Amol Bhandarwar
    • 1
  • Harshwardhan L. Jain
    • 1
  • Kanjaksha Ghosh
    • 2
  1. 1.Department of PediatricsGovernment Medical CollegeNagpurIndia
  2. 2.National Institute of ImmunohaematologyMumbaiIndia
  3. 3.Department of PediatricsGovernement Medical CollegeNagpurIndia

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