Indian Pediatrics

, Volume 50, Issue 6, pp 573–577 | Cite as

Growth and neurodevelopmental outcome of VLBW infants at 1 year corrected age

  • Manoj ModiEmail author
  • S. Saluja
  • N. Kler
  • A. Batra
  • A. Kaur
  • P. Garg
  • A. Soni
  • P. Suman
Research Paper



To evaluate growth and neurodevelopmental outcome of very low birth weight infants (VLBW) and compare with term normal birth weight infants (NBW) till 12 months corrected age.


A prospective cohort study


Tertiary care neonatal unit in northern India


37 VLBW infants and 35 NBW infants born between January 2007 and December 2007.


Anthropometric measurements were recorded and Z-scores were computed serially at birth, discharge, 40 weeks post menstrual age (PMA), and at 1, 3, 6 and 12 months of corrected age. Developmental quotient (DQ) at 12 months corrected age was assessed.


Z-scores for weight, length and head circumference (HC) at birth were −1.21(±0.92), −0.98(±1.32) and −0.70(±1.14), respectively for VLBW infants and −0.37(±0.72), −0.11(±0.96) and 0.05(±0.73) respectively for NBW infants. VLBW infants had a significant drop in all Z-scores by discharge (P<0.001). There was a catch up to birth scores by 12 month age. VLBW infants had significantly lower Z-scores for weight, length and HC at one year corrected age as compared to NBW infants (P =0.01, 0.04 and 0.001, respectively). DQ at 12 months was significantly lower in VLBW infants (91.5+7.8) than NBW infants (97.5±5.3) (P <0.001). DQ of small for gestational age (SGA) and appropriate for gestational age (AGA) VLBW infants was comparable.


VLBW infants falter in their growth during NICU stay with a catch-up later during infancy. In comparison to NBW infants, they continue to lag in their physical growth and neurodevelopment at 1 year of corrected age.

Key words

Development Neonate Outcome Very low birth weight 


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  1. 1.
    Hack M, Schluchter M, Cartar L, Rahman M, Cuttler L, Borawski E. Growth of very low birth weight infants to age 20 years. Pediatrics. 2003;112:30–38.CrossRefGoogle Scholar
  2. 2.
    Ho JJ, Amar HS, Mohan AJ, Hon TH. Neurodevelopmental outcome of very low birth weight babies admitted to a Malaysian nursery. J Pediatr Child Health. 1999;35:175–180.CrossRefGoogle Scholar
  3. 3.
    Boo NY, Ong LC, Lye MS, Chandran V, Teoh SL, Zamratol S, et al. Comparison of morbidities in very low birthweight and normal birthweight infants during the first year of life in a developing country. J Paediatr Child Health. 1996;32:439–444.PubMedCrossRefGoogle Scholar
  4. 4.
    Chaudhari S, Otiv M, Chitale A, Pandit A, Hoge M. Pune Low Birth Weight Study — Cognitive abilities and educational performance at twelve years. Indian Pediatr. 2004;41:121–128.PubMedGoogle Scholar
  5. 5.
    Bhargava SK, Ramji S, Srivastava S, Sachdev HPS, Kapani V, Datta V, et al. Growth and sexual maturation of low birth weight children: a 14 year follow up. Indian Pediatr. 1995;32:963–970.PubMedGoogle Scholar
  6. 6.
    Bavdekar AR, Vaidya UV, Bhave SA, Pandit AN. Catch up growth and its determinants in low birth weight babies: a study using Z scores. Indian Pediatr. 1994;31:1483–1490.PubMedGoogle Scholar
  7. 7.
    Mukhopadhyay K, Malhi P, Mahajan R, Narang A. Neurodevelopmental and behavioral outcome of very low birth weight babies at corrected age of 2 years. Indian J Pediatr. 2010;77:963–967.PubMedCrossRefGoogle Scholar
  8. 8.
    Fenton TR. Preterm Growth Chart 2003calculations. Available from: URL: Growth Chart calculations.xls. Accessed on 10 February, 2009.
  9. 9.
    New WHO growth charts. Available from:URL: Accessed on 10 February 2009.
  10. 10.
    Misra N, Pathak P. Developmental assessment scales for Indian Infants (DASII): Manual, Baroda, M.S. University of Baroda, 1996.Google Scholar
  11. 11.
    Westerberg A C, Henriksen C, Ellingvåg A, Veierød MB, Júlíusson PB, Nakstad B. First year growth among very low birth weight infants. Acta Pædiatrica. 2010;99:556–562.PubMedCrossRefGoogle Scholar
  12. 12.
    Ehrenkranz RA, Younes N, Lemons JA, Fanaroff AA, Donovan EF, Wright LL. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics. 1999;104:280–289.PubMedCrossRefGoogle Scholar
  13. 13.
    Saluja S, Modi M, Kaur A, Batra A, Soni A, Garg P, et al. Growth of very low birth weight infants during hospital stay. Indian Pediatr. 2010;47:851–856PubMedCrossRefGoogle Scholar
  14. 14.
    American Academy of Pediatrics, Committee on Nutrition. Nutritional needs of low-birth-weight infants. Pediatrics. 1977;60:519–530.Google Scholar
  15. 15.
    Marks KA, Reichman B, Lusky A, Zmora E; Israel Neonatal Network. Fetal growth and postnatal growth failure in very-low-birthweight infants. Acta Paediatr. 2006;95:236–242.PubMedCrossRefGoogle Scholar
  16. 16.
    Mackay CA, Ballot DE, Cooper PA. Growth of a cohort of very low birth weight infants in Johannesburg, South Africa. BMC Pediatrics. 2011;11:50–55.PubMedCrossRefGoogle Scholar
  17. 17.
    Saigal S, Stoskopf B, Streiner D, Paneth N, Pinelli J, Boyle M. Growth trajectories of extremely low birth weight infants from birth to young adulthood: A longitudinal, population-based study. Pediatr Res. 2006;60:751–758.PubMedCrossRefGoogle Scholar
  18. 18.
    Procianoy RS, Koch MS, Silveira RC. Neurodevelopmental outcome of appropriate and small for gestational age very low birth weight infants. J Child Neurol. 2009;24:788–794.PubMedCrossRefGoogle Scholar
  19. 19.
    Larroque B, Bertrais S, Czernichow P, Leger J. School difficulties in 20-year-olds who were born small for gestational age at term in a regional cohort study. Pediatrics. 2001;108:111–115.PubMedCrossRefGoogle Scholar
  20. 20.
    Gutbrod T, Wolke D, Soehne B, Ohrt B, Riegel K. Effects of gestation and birth weight on the growth and development of very low birthweight small for gestational age infants: a matched group comparison. Arch Dis Child (Fetal Neonatal Ed). 2000;82:F208–F214.CrossRefGoogle Scholar
  21. 21.
    Latal-Hajnal B, von Siebenthal K, Kovari H, Bucher HU, Largo RH. Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome. J Pediatr. 2003;143:163–170.PubMedGoogle Scholar
  22. 22.
    Hack M, Breslau N, Weissman B, Aram D, Klein N, Borawski E. Effect of very low birth weight and subnormal head size on cognitive abilities at school age. N Engl J Med. 1991;325:231–237.PubMedCrossRefGoogle Scholar
  23. 23.
    Gross SJ, Oehler JM, Eckerman. CO. Head growth and developmental outcome in very low birthweight infants. Pediatrics. 1983;71:70–75.PubMedGoogle Scholar

Copyright information

© Indian Academy of Pediatrics 2013

Authors and Affiliations

  • Manoj Modi
    • 1
    • 3
    Email author
  • S. Saluja
    • 1
  • N. Kler
    • 1
  • A. Batra
    • 1
  • A. Kaur
    • 1
  • P. Garg
    • 1
  • A. Soni
    • 1
  • P. Suman
    • 2
  1. 1.Departments of NeonatologySir Ganga Ram HospitalNew DelhiIndia
  2. 2.Pediatrics, Center for Child HealthSir Ganga Ram HospitalNew DelhiIndia
  3. 3.Department of Neonatology, Center for Child HealthSir Ganga Ram HospitalNew DelhiIndia

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