Indian Pediatrics

, Volume 50, Issue 5, pp 501–503 | Cite as

Plasma endothelial microparticles, TNF-α and IL-6 in Kawasaki disease

  • Zhen Tan
  • Yan Yuan
  • Sun Chen
  • Yi Chen
  • Tong-Xin Chen
Research Brief


We studied the levels of endothelial microparticles (EMPs), IL-6, and TNF-α in patients with Kawasaki disease (KD). EMPs were enumerated by flow cytometry, while IL-6 and TNF-α were measured using enzyme-linked immunosorbent assay. EMPs and IL-6 were elevated in KD, the level of TNF-α in KD was not different from disease controls, but higher than healthy controls. EMPs were positively correlated with TNF-α and negatively correlated with albumin. Elevated level of EMPs, a biomarker of endothelial cells damage, concomitant with increased levels of TNF-α and IL-6, is seen in patients with KD.

Key words

Endothelial microparticles Interleukin-6 Kawasaki disease Tumor necrosis factor-α 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Burns JC, Glode MP. Kawasaki syndrome. Lancet. 2004;364:533–544.PubMedCrossRefGoogle Scholar
  2. 2.
    Jimenez JJ, Jy W, Mauro LM, Horstman LL, Bidot CJ, Ahn YS. Endothelial microparticles (EMP) as vascular disease markers. Adv Clin Chem. 2005;39:131–157.PubMedCrossRefGoogle Scholar
  3. 3.
    Clarke LA, Hong Y, Eleftheriou D, Shah V, Arrigoni F, Klein NJ, et al. Endothelial injury and repair in systemic vasculitis of the young. Arthritis Rheum. 2010;62:1770–1780.PubMedCrossRefGoogle Scholar
  4. 4.
    Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and longterm management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. 2004;114:1708–1733.PubMedCrossRefGoogle Scholar
  5. 5.
    Enjeti AK, Lincz LF, Seldon M. Detection and measurement of microparticles: an evolving research tool for vascular biology. Semin Thromb Hemost. 2007;33:771–779.PubMedCrossRefGoogle Scholar
  6. 6.
    Enjeti AK, Lincz LF, Seldon M. Microparticles in health and disease. Semin Thromb Hemost. 2008;34:683–691.PubMedCrossRefGoogle Scholar
  7. 7.
    Widemann A, Sabatier F, Arnaud L, Bonello L, Al-Massarani G, Paganelli F, et al. CD146-based immunomagnetic enrichment followed by multiparameter flow cytometry: a new approach to counting circulating endothelial cells. J Thromb Haemost. 2008;6:869–876.PubMedCrossRefGoogle Scholar
  8. 8.
    Harrison M, Murphy RP, O’Connor PL, O’Gorman DJ, McCaffrey N, Cummins PM, et al. The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. Eur J Appl Physiol. 2009;106:555–562PubMedCrossRefGoogle Scholar
  9. 9.
    Kuo HC, Liang CD, Wang CL, Yu HR, Hwang KP, Yang KD. Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease. Acta Paediatr. 2010;99:1578–1583.PubMedCrossRefGoogle Scholar
  10. 10.
    Chang J, Lu JR, Liang D. The function of Th1/Th2 cells in children with acute Kawasaki disease. Zhonghua Er Ke Za Zhi. 2006;44:377–378.PubMedGoogle Scholar
  11. 11.
    Sofi MH, Li W, Kaplan MH, Chang CH. Elevated IL-6 expression in CD4 T cells via PKCtheta and NF-kappaB induces Th2 cytokine production. Mol Immunol. 2009;46:1443–1450.PubMedCrossRefGoogle Scholar
  12. 12.
    Galeotti C, Bayry J, Kone-Paut I, Kaveri SV. Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin. Autoimm Rev. 2010;9:441–448.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Pediatrics 2013

Authors and Affiliations

  • Zhen Tan
    • 1
  • Yan Yuan
    • 2
  • Sun Chen
    • 1
  • Yi Chen
    • 1
  • Tong-Xin Chen
    • 3
    • 4
  1. 1.Department of PediatricsXinhua Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Department of Public Health SciencesUniversity of AlbertaAlbertaCanada
  3. 3.Department of Clinical Immunology/Department of Nephrology and Rheumatology, Children’s Hospital of ShanghaiShanghai Jiao Tong UniversityShanghaiChina
  4. 4.Department of Clinical Immunology/Department of Nephrology and Rheumatology, Children’s Hospital of ShanghaiShanghai Jiao Tong UniversityShanghaiChina

Personalised recommendations