Neurodevelopmental evaluation of very low birth weight infants with sepsis at 18 to 24 months’ corrected age
In this cohort study, neurodevelopmental outcome of 20 of 24 surviving very low birth weight infants with sepsis followed-up between 2008 and 2009 was compared with 20 control (uninfected infants). We found that plasma interleukin-6 and C-reactive protein values were negatively correlated with mental developmental index scores (r= −0.33, P= 0.03 and r= −0.40, P= 0.01, respectively) at 18 to 24 months’ corrected age. The results of this study indicate that sepsis experienced in the neonatal period seems to be related to low mental developmental index scores at 18 to 24 months’ corrected age.
Key wordsNeurodevelopmental outcome Preterm Sepsis
- 2.Schmidt B, Asztalos EV, Roberts RS, Robert-son CM, Sauve RS, Whitûeld MF. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indometh-acin prophylaxis in preterms. JAMA. 2003;289:1124–1129.PubMedCrossRefGoogle Scholar
- 7.Bayley N. Bayley Scales of Infant Development II. San Antonio, TX: Psychological Corp; 1993.Google Scholar