Indian Pediatrics

, Volume 47, Issue 11, pp 959–963 | Cite as

Tolerance of baby cleansers in infants: A randomized controlled trial

  • Maria Victoria Dizon
  • Carlos Galzote
  • Ricco Estanislao
  • Noble Mathew
  • Rashmi Sarkar
Short Communication


This randomized controlled trial was conducted to evaluate the tolerability of a new baby cleanser formulation — Johnson’s Top-to-Toe cleanser (JTT) on infantile skin. 180 healthy infants (60 in each group) were enrolled and JTT Sebamed Baby Liquid cleanser (SM), and lukewarm tap water were used on the skin of the subjects as whole body cleansers twice a week for 2 weeks. Assessment was done at baseline, 1 week and 2 weeks clinically by a dermato-logist, instrumentally, and by the parents. Clinical assessment (erythema, edema, dryness and scaling); skin moisture content; skin surface pH; trans-epidermal water loss; skin oxyhemoglobin and deoxyhemoglobin; and consu-mer satisfaction were the outcome measures. There was no significant erythema, edema, dryness, or scaling elicited by any of the three test components. Parents did not report any side-effects. All the three studied interventions used as whole body cleansers were efficacious and well tolerated by infants.

Key words

Baby cleanser Infant Moisture Tolerability Epidermal water loss Skin 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Sarkar R. Care of the skin. In: Gupta P (editor). Essential Pediatric Nursing. New Delhi: CBS Publisher and Distributors; 2007. p. 217–226.Google Scholar
  2. 2.
    Schmid Wendtner MH, Korting Hl. The pH of the skin surface and its impact on the barriers function. Skin Pharmacol Physiol 2006; 19: 296–302.CrossRefPubMedGoogle Scholar
  3. 3.
    Gfatter R, Hackl P, Braun F. Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants. Dematology 1997; 195: 258–262.CrossRefGoogle Scholar
  4. 4.
    Tyebkan G. Skin cleansing in neonates and infantsbasics of cleansers. Indian J Pediatr 2002; 69: 767–769.CrossRefGoogle Scholar
  5. 5.
    Dhar S. Newborn skin care revisited. Indian J Dematol 2007 52: 1–4.CrossRefGoogle Scholar
  6. 6.
    Giusti F, Martella A, Bertoni L, Seidenarr S. Skin barrier, hydration and pH of the skin of infants under 2 year of age. Pediatr Dematol 2001; 18: 93–96.CrossRefGoogle Scholar
  7. 7.
    Wilhelm KP, Civa A, Maibach H. Skin aging: Effect on transepidermal water loss, stratum corneum hydration, skin surface pH and casual sebum content. Arch Dematol 1991; 127: 1806–1809.CrossRefGoogle Scholar
  8. 8.
    Thibodeau A, Amari. S. Maintenance and repair of the hydrolipidic film with skin molecular mimetic emollients and surfactants. Available from: Accessed on 28th June, 2009.
  9. 9.
    Draelos ZD. Sensitive skin: perceptions, evaluation and treatment. Am J Contact Dermat 1997; 8: 67–68.CrossRefPubMedGoogle Scholar
  10. 10.
    Ananthapadmanabhan KP, Moore DJ, Subramanyam K, Misra M, Meyer F. Cleansing without compromise:the imact of cleansers on the skin barrier and the technology of mild cleansing. Dermatol Ther 2004;17(Supl): 16–25.CrossRefPubMedGoogle Scholar
  11. 11.
    Kuehl BL, Fyfe KS, Shear NH. Cutaneous cleansers. Skin therapy 2003; 8: 1–4.Google Scholar
  12. 12.
    Morelli JG, William WL. Soaps and shampoos in pediatric practice. Pediatrics 1987; 5: 634–637.Google Scholar
  13. 13.
    Peck SM, Kantor I, Bioday M. Alkaline toilet.soaps are not the cleanser of choice in routine pediatric care. A cross-over study comparing alkaline toilet soap against a neutral detergent as a routine cleansers. Clin Pediatr 1964; 3: 42–45.CrossRefGoogle Scholar
  14. 14.
    Tyebkhan G. A study in the pH of the various soaps available in the Indian market. Indian J Dermatol Venereol Leprol 2001; 67: 290–291.PubMedGoogle Scholar

Copyright information

© Indian Academy of Pediatrics 2010

Authors and Affiliations

  • Maria Victoria Dizon
    • 1
    • 5
  • Carlos Galzote
    • 2
  • Ricco Estanislao
    • 3
  • Noble Mathew
    • 3
  • Rashmi Sarkar
    • 4
  1. 1.University of Santo Tomas HospitalManilaPhilippines
  2. 2.Asia-Pacific Skin Testing CentreMetro ManilaPhilippines
  3. 3.Johnson & Johnson Pacific Pvt LtdNSWAustralia
  4. 4.Safdarjung HospitalNew DelhiIndia
  5. 5.Department of DermatologyUniversity of Santo TomasEspana, ManilaPhilippines

Personalised recommendations