ASENT 2019 Abstracts
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Active Immunotherapeutic Vaccine Platform Targeting Endogenous Proteins for the Treatment of Neurodegenerative Diseases
Sharon Tamir; Hui Jing Yu, PhD; JC Dodart, PhD; and Chang Yi Wang, PhD; all of United Neuroscience
United Neuroscience (UNS) is pioneering a new class of active immunotherapeutics to promote brain health, focusing on delivering safe, effective and accessible medicines to treat and ultimately prevent Alzheimer’s (AD), Parkinson’s disease (PD) and other neurological disorders. Leveraging a proven vaccine platform that has commercialized one of the only licensed active immunotherapies against an endogenous protein in the world and has scaled up manufacture to over 500 million doses annually for other animal indications.
Success for a vaccine approach aimed at endogenous targets relies on the ability to break immune tolerance and generate a humoral antibody response against the desired epitopes, while also avoiding T-cell-mediated autoimmune reactions. UNS has evolved a...