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Neurotherapeutics

, Volume 16, Issue 1, pp 100–104 | Cite as

Directional Deep Brain Stimulation

  • Frank SteigerwaldEmail author
  • Cordula Matthies
  • Jens Volkmann
Review
  • 277 Downloads

Abstract

Over the last years, deep brain stimulation has seen many technological innovations. New electrode designs allowing to direct the current flow not only in the vertical but also in the horizontal plane are the most recent. We summarize the concept of “directional deep brain stimulation” with its opportunities and challenges and the available study data and discuss the use of imaging techniques to assist programming deep brain stimulation devices.

Key Words

Deep brain stimulation directional DBS VTA modeling 

Supplementary material

13311_2018_667_MOESM1_ESM.pdf (1.2 mb)
ESM 1 (PDF 1225 kb)

References

  1. 1.
    Blomstedt P, Hariz GM, Hariz MI, Koskinen LO. Thalamic deep brain stimulation in the treatment of essential tremor: a long-term follow-up. Br J Neurosurg. 2007;21(5):504–9.CrossRefGoogle Scholar
  2. 2.
    Borretzen MN, Bjerknes S, Saehle T, Skjelland M, Skogseid IM, Toft M, et al. Long-term follow-up of thalamic deep brain stimulation for essential tremor - patient satisfaction and mortality. BMC Neurol. 2014;14:120.CrossRefGoogle Scholar
  3. 3.
    Kumar R, Lozano AM, Sime E, Lang AE. Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor. Neurology. 2003;61(11):1601–4.CrossRefGoogle Scholar
  4. 4.
    Zhang K, Bhatia S, Oh MY, Cohen D, Angle C, Whiting D. Long-term results of thalamic deep brain stimulation for essential tremor. J Neurosurg. 2010;112(6):1271–6.CrossRefGoogle Scholar
  5. 5.
    Rizzone MG, Fasano A, Daniele A, Zibetti M, Merola A, Rizzi L, et al. Long-term outcome of subthalamic nucleus DBS in Parkinson’s disease: from the advanced phase towards the late stage of the disease? Parkinsonism Relat Disord. 2014;20(4):376–81.CrossRefGoogle Scholar
  6. 6.
    Toft M, Lilleeng B, Ramm-Pettersen J, Skogseid IM, Gundersen V, Gerdts R, et al. Long-term efficacy and mortality in Parkinson’s disease patients treated with subthalamic stimulation. Mov Disord. 2011;26(10):1931–4.CrossRefGoogle Scholar
  7. 7.
    Bruggemann N, Kuhn A, Schneider SA, Kamm C, Wolters A, Krause P, et al. Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia. Neurology. 2015;84(9):895–903.CrossRefGoogle Scholar
  8. 8.
    FitzGerald JJ, Rosendal F, de Pennington N, Joint C, Forrow B, Fletcher C, et al. Long-term outcome of deep brain stimulation in generalised dystonia: a series of 60 cases. J Neurol Neurosurg Psychiatry. 2014;85(12):1371–6.CrossRefGoogle Scholar
  9. 9.
    Meoni S, Fraix V, Castrioto A, Benabid AL, Seigneuret E, Vercueil L, et al. Pallidal deep brain stimulation for dystonia: a long term study. J Neurol Neurosurg Psychiatry. 2017;88(11):960–7.CrossRefGoogle Scholar
  10. 10.
    Baizabal-Carvallo JF, Jankovic J. Movement disorders induced by deep brain stimulation. Parkinsonism Relat Disord. 2016;25:1–9.CrossRefGoogle Scholar
  11. 11.
    Maks CB, Butson CR, Walter BL, Vitek JL, McIntyre CC. Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes. J Neurol Neurosurg Psychiatry. 2009;80(6):659–66.CrossRefGoogle Scholar
  12. 12.
    Horn A, Neumann WJ, Degen K, Schneider GH, Kuhn AA. Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus. Hum Brain Mapp. 2017.  https://doi.org/10.1002/hbm.23594.
  13. 13.
    Neumann WJ, Horn A, Ewert S, Huebl J, Brucke C, Slentz C, et al. A localized pallidal physiomarker in cervical dystonia. Ann Neurol. 2017;82(6):912–24.CrossRefGoogle Scholar
  14. 14.
    Wodarg F, Herzog J, Reese R, Falk D, Pinsker MO, Steigerwald F, et al. Stimulation site within the MRI-defined STN predicts postoperative motor outcome. Mov Disord. 2012;27(7):874–9.CrossRefGoogle Scholar
  15. 15.
    Anderson DN, Osting B, Vorwerk J, Dorval AD, Butson CR. Optimized programming algorithm for cylindrical and directional deep brain stimulation electrodes. J Neural Eng. 2018;15(2):026005.CrossRefGoogle Scholar
  16. 16.
    Contarino MF, Bour LJ, Verhagen R, Lourens MA, de Bie RM, van den Munckhof P, et al. Directional steering: A novel approach to deep brain stimulation. Neurology. 2014;83(13):1163–9.CrossRefGoogle Scholar
  17. 17.
    Pollo C, Kaelin-Lang A, Oertel MF, Stieglitz L, Taub E, Fuhr P, et al. Directional deep brain stimulation: an intraoperative double-blind pilot study. Brain. 2014;137(Pt 7):2015–26.CrossRefGoogle Scholar
  18. 18.
    Steigerwald F, Muller L, Johannes S, Matthies C, Volkmann J. Directional deep brain stimulation of the subthalamic nucleus: A pilot study using a novel neurostimulation device. Mov Disord. 2016;31(8):1240–3.CrossRefGoogle Scholar
  19. 19.
    Dembek TA, Reker P, Visser-Vandewalle V, Wirths J, Treuer H, Klehr M, et al. Directional DBS increases side-effect thresholds-A prospective, double-blind trial. Mov Disord. 2017;32(10):1380–8.CrossRefGoogle Scholar
  20. 20.
    Rebelo P, Green AL, Aziz TZ, Kent A, Schafer D, Venkatesan L, et al. Thalamic Directional Deep Brain Stimulation for tremor: Spend less, get more. Brain Stimul. 2018.Google Scholar
  21. 21.
    Volkmann J, Chabardes S, Steinke GK, Carcieri S, Van Dyck N. (P2020) DIRECT DBS: A prospective, multi-center clinical trial with blinding for a directional DBS lead. Movement Disord. 2016;31(S2):666.Google Scholar
  22. 22.
    Ten Brinke TR, Odekerken VJJ, Dijk JM, van den Munckhof P, Schuurman PR, de Bie RMA. Directional Deep Brain Stimulation: First experiences in centers across the globe. Brain Stimul. 2018;11(4):949–50.CrossRefGoogle Scholar
  23. 23.
    Reinacher PC, Kruger MT, Coenen VA, Shah M, Roelz R, Jenkner C, et al. Determining the Orientation of Directional Deep Brain Stimulation Electrodes Using 3D Rotational Fluoroscopy. AJNR Am J Neuroradiol. 2017;38(6):1111–6.CrossRefGoogle Scholar
  24. 24.
    Sitz A, Hoevels M, Hellerbach A, Gierich A, Luyken K, Dembek TA, et al. Determining the orientation angle of directional leads for deep brain stimulation using computed tomography and digital x-ray imaging: A phantom study. Med Phys. 2017;44(9):4463–73.CrossRefGoogle Scholar
  25. 25.
    Hunsche S, Neudorfer C, Majdoub FE, Maarouf M, Sauner D. Determining the Rotational Orientation of Directional Deep Brain Stimulation Leads Employing Flat-Panel Computed Tomography. Oper Neurosurg (Hagerstown). 2018.  https://doi.org/10.1093/ons/opy163

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2018

Authors and Affiliations

  1. 1.Department of NeurologyUniversity Hospital WürzburgWürzburgGermany
  2. 2.Department of NeurosurgeryUniversity Hospital WürzburgWürzburgGermany

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