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Neurotherapeutics

, Volume 15, Issue 2, pp 417–429 | Cite as

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

  • Nian-Sheng Tzeng
  • Chi-Hsiang Chung
  • Fu-Huang Lin
  • Chien-Ping Chiang
  • Chin-Bin Yeh
  • San-Yuan Huang
  • Ru-Band Lu
  • Hsin-An Chang
  • Yu-Chen Kao
  • Hui-Wen Yeh
  • Wei-Shan Chiang
  • Yu-Ching Chou
  • Chang-Huei Tsao
  • Yung-Fu Wu
  • Wu-Chien Chien
Original Article

Abstract

This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan’s National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort. This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. Thus, patients with HSV infections may have a 2.56-fold increased risk of developing dementia. A risk reduction of dementia development in patients affected by HSV infections was found upon treatment with anti-herpetic medications (adjusted HR = 0.092 [95% CI 0.079-0.108], P < 0.001). The usage of anti-herpetic medications in the treatment of HSV infections was associated with a decreased risk of dementia. These findings could be a signal to clinicians caring for patients with HSV infections. Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations.

Key Words

Herpes simplex virus Dementia National Health Insurance Research Database Anti-herpetic medications Cohort study 

Notes

Acknowledgments

This study was supported by grants from Tri-Service Hospital Research Foundation (TSGH-C105-130, TSGH-C106-002, and TSGH-C107-004), and the sponsor has no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Required Author Forms

Disclosure forms provided by the authors are available with the online version of this article.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

13311_2018_611_MOESM1_ESM.pdf (1.2 mb)
ESM 1 (PDF 1224 kb)
13311_2018_611_MOESM2_ESM.docx (20 kb)
Supplementary Table 1 (DOCX 20 kb)

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Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2018

Authors and Affiliations

  • Nian-Sheng Tzeng
    • 1
    • 2
  • Chi-Hsiang Chung
    • 3
    • 4
    • 5
  • Fu-Huang Lin
    • 4
  • Chien-Ping Chiang
    • 6
  • Chin-Bin Yeh
    • 1
    • 7
  • San-Yuan Huang
    • 1
    • 7
  • Ru-Band Lu
    • 1
    • 8
    • 9
    • 10
    • 11
    • 12
  • Hsin-An Chang
    • 1
    • 2
  • Yu-Chen Kao
    • 1
    • 13
  • Hui-Wen Yeh
    • 1
  • Wei-Shan Chiang
    • 1
    • 14
  • Yu-Ching Chou
    • 4
  • Chang-Huei Tsao
    • 5
  • Yung-Fu Wu
    • 5
  • Wu-Chien Chien
    • 4
    • 5
  1. 1.Department of Psychiatry, Tri-Service General Hospital, School of MedicineNational Defense Medical CenterTaipeiRepublic of China
  2. 2.Student Counseling CenterNational Defense Medical CenterTaipeiRepublic of China
  3. 3.Taiwanese Injury Prevention and Safety Promotion AssociationTaipeiRepublic of China
  4. 4.School of Public HealthNational Defense Medical CenterTaipeiRepublic of China
  5. 5.Department of Medical Research, Tri-Service General HospitalNational Defense Medical CenterTaipei CityRepublic of China
  6. 6.Department of Dermatology, Tri-Service General Hospital, School of MedicineNational Defense Medical CenterTaipeiRepublic of China
  7. 7.Graduate Institute of Medical SciencesNational Defense Medical CenterTaipeiRepublic of China
  8. 8.Division of Clinical Psychology, Institute of Allied Health Sciences, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  9. 9.Department of Psychiatry, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  10. 10.Institute of Behavioral Medicine, College of MedicineNational Cheng Kung UniversityTainanRepublic of China
  11. 11.Department of PsychiatryNational Cheng Kung University HospitalTainanRepublic of China
  12. 12.Center for Neuropsychiatric ResearchNational Health Research InstituteMiaoli CountyRepublic of China
  13. 13.Department of Psychiatry, Tri-Service General Hospital, Song-Shan BranchNational Defense Medical CenterTaipeiRepublic of China
  14. 14.Department and Institute of MathematicsTamkang UniversityNew Taipei CityRepublic of China

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