, Volume 15, Issue 1, pp 156–175 | Cite as

S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

  • Jin Gao
  • Catherine M. Cahill
  • Xudong Huang
  • Joshua L. Roffman
  • Stefania Lamon-Fava
  • Maurizio Fava
  • David Mischoulon
  • Jack T. Rogers
Current Perspectives


S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and the disturbance in transmethylation pathways. Also included in this review are the present-day applications of SAMe in the treatment in these diseases in each age group.


S-Adenosyl-methionine Transmethylation Pathway Psychiatric disease Neurodegenerative disease 



Dr. Jin Gao was supported by the grant from National Natural Science Foundation of China (, No:81501170) Dr. Jack Rogers is supported by 5R01MH102279-03 (M. Fava, MGH), and was a recipient of The Zenith Fellows Award of Alzheimer’s Association and of a National Institutes of Health grant (R21NS077079-01A1). Dr. Xudong Huang and JTR are supported by a National Institutes of Health grant (1R01AG056614-01).

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Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2018

Authors and Affiliations

  • Jin Gao
    • 1
    • 2
    • 3
  • Catherine M. Cahill
    • 2
  • Xudong Huang
    • 2
  • Joshua L. Roffman
    • 1
  • Stefania Lamon-Fava
    • 4
  • Maurizio Fava
    • 1
  • David Mischoulon
    • 1
  • Jack T. Rogers
    • 2
  1. 1.Department of PsychiatryMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Neurochemistry Laboratory, Department of PsychiatryMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Department of Clinical PsychologyQilu Hospital of Shandong UniversityQingdaoChina
  4. 4.Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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