, Volume 11, Issue 3, pp 606–611 | Cite as

Prestroke Statins, Progression of White Matter Hyperintensities, and Cognitive Decline in Stroke Patients with Confluent White Matter Hyperintensities

  • Yunyun Xiong
  • Adrian Wong
  • Margherita Cavalieri
  • Reinhold Schmidt
  • Winnie W. C. Chu
  • Xinfeng Liu
  • Ka Sing Wong
  • Vincent MokEmail author
Original Article


Cerebral white matter hyperintensities (WMH) are a consequence of cerebral small vessel disease. Statins have been shown to reduce recurrent stroke among patients with various stroke subtypes, including lacunar stroke, which also arises from small vessel disease. In this study, we investigated the hypothesis that prestroke statin use would reduce the progression of WMH and/or cognitive decline among stroke patients with confluent WMH. Patients (n = 100) were participants of the VITAmins To Prevent Stroke magnetic resonance imaging substudy. All patients had confluent WMH on magnetic resonance imaging at baseline. Eighty-one patients completed the 2-year follow-up. We assessed general cognition and executive function using the mini-mental state examination and Mattis dementia rating scale–initiation/perseveration subscale, respectively. We compared the change in volume of WMH and cognition between prestroke statin use and prestroke nonstatin use groups. We also evaluated the effects of prestroke statin use on incident lacunes and microbleeds. The prestroke statin use group (n = 51) had less WMH volume progression (1.54 ± 4.52 cm3 vs 5.01 ± 6.00 cm3, p = 0.02) compared with the prestroke nonstatin use group (n = 30). Multivariate linear regression modeling identified prestroke statin use as an independent predictor of WMH progression (β = –0.31, p = 0.008). Prestroke statin use was also associated with less decline (Mattis dementia rating scale–initiation/perseveration subscale; β = 0.47, p = 0.001). No association was observed with changes in mini-mental state examination scores. There were no between group differences on incident lacunes or incident microbleeds. Prestroke statin use may reduce WMH progression and decline in executive function in stroke patients with confluent WMH.


Statins White matter hyperintensities Stroke Cognitive decline 



This work was supported by a 2005/2006 Earmarked Grant CUHK 4317/04 M.

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Conflict of Interests


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Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2014

Authors and Affiliations

  • Yunyun Xiong
    • 1
    • 2
  • Adrian Wong
    • 4
  • Margherita Cavalieri
    • 5
  • Reinhold Schmidt
    • 5
  • Winnie W. C. Chu
    • 3
  • Xinfeng Liu
    • 1
  • Ka Sing Wong
    • 2
  • Vincent Mok
    • 2
    Email author
  1. 1.Department of Neurology, Jinling HospitalNanjing University School of MedicineNanjingPeople’s Republic of China
  2. 2.Department of Medicine and TherapeuticsThe Chinese University of Hong KongShatinPeople’s Republic of China
  3. 3.Department of Radiology and Organ ImagingThe Chinese University of Hong KongShatinPeople’s Republic of China
  4. 4.Department of Psychological Studies and Center for Psychosocial Health and AgingThe Hong Kong Institute of EducationTaipoPeople’s Republic of China
  5. 5.Department of NeurologyMedical University GrazGrazAustria

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