Neurotherapeutics

, Volume 10, Issue 4, pp 734–741

Epigenetics and Psychiatry

Review

DOI: 10.1007/s13311-013-0213-6

Cite this article as:
Mahgoub, M. & Monteggia, L.M. Neurotherapeutics (2013) 10: 734. doi:10.1007/s13311-013-0213-6

Abstract

Psychiatric disorders including major depressive disorder, drug addiction, and schizophrenia are debilitating illnesses with a multitude of complex symptoms underlying each of these disorders. In recent years, it has become appreciated that the onset and development of these disorders goes beyond the one gene–one disease approach. Rather, the involvement of many genes is likely linked to these illnesses, and regulating the activation or silencing of gene function may play a crucial role in contributing to their pathophysiology. Epigenetic modifications such as histone acetylation and deacetylation, as well as DNA methylation can induce lasting and stable changes in gene expression, and have therefore been implicated in promoting the adaptive behavioral and neuronal changes that accompany each of these illnesses. In this review we will discuss some of the latest work implicating a potential role for epigenetics in psychiatric disorders, namely, depression, addiction, and schizophrenia as well as a possible role in treatment.

Keywords

Epigenetics Depression Addiction Schizophrenia Histone 

Supplementary material

13311_2013_213_MOESM1_ESM.pdf (653 kb)
ESM 1(PDF 653 kb)

Copyright information

© The American Society for Experimental NeuroTherapeutics, Inc. 2013

Authors and Affiliations

  1. 1.Department of NeuroscienceUniversity of Texas Southwestern Medical CenterDallasUSA

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