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Updates in Surgery

, Volume 71, Issue 4, pp 747–749 | Cite as

Liver transplantation using a whole graft from a deceased donor affected with Osler–Weber–Rendu syndrome: a first ever

  • Salvatore GruttadauriaEmail author
  • Duilio Pagano
  • Rosa Liotta
Letter to the Editor
  • 38 Downloads

Dear Editors-in-Chief,

The critical use of extended criteria donor (ECD) grafts has allowed patients on the waiting-list for liver transplantation (LT) to have a greater chance of being transplanted for end-stage liver disease and/or primary hepatic tumor. Osler–Weber–Rendu syndrome, or hereditary hemorrhagic telangiectasia (HHT), is a rare autosomal dominant genetic vascular disease characterized by arteriovenous malformations (AVMs) and pathological angiogenesis causing a fibro-vascular systemic dysplasia, fragility of the vascular wall, and dilatation and consequent rupture of the vessels. We report the first LT recipient who received a whole liver graft from a young brain-dead donor affected with HHT to introduce a broader concept in this field of medicine in which HHT is usually a primary etiology for liver transplant [ 1, 2, 3]. The organ donor was a 30-year-old, blood group A male, who suffered from a spontaneous brain hemorrhage due to cerebral AVM rupture 2 weeks before the...

Keywords

Brain-dead donation/donor Liver transplantation Osler–Weber–Rendu syndrome Arteriovenous malformation 

Abbreviations

AVM

Arteriovenous malformation

DBD

Donation/donor after brain death

ECD

Extended criteria donor

HHT

Hereditary hemorrhagic telangiectasia

LT

Liver transplantation

Notes

Acknowledgements

The authors would like to thank Warren Blumberg for his help in editing this paper.

Author contributions

SG: critical revision of article, approval of article. DP: concept/design, data analysis/interpretation, drafting article. RL: critical revision of article, histology revision.

Compliance with ethical standards

Conflict of interest

The authors of this manuscript have no conflict of interest to disclose as described by Updates in Surgery. We hereby certify that all the authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Research involving human participants and/or animals

The research involved the human participant (patient) and it has complied with all relevant national guidelines and institutional policies.

Informed consent

Informed consent was correctly obtained.

Supplementary material

13304_2019_676_MOESM1_ESM.pdf (2.9 mb)
Supplementary material 1 (PDF 3005 kb)

References

  1. 1.
    Alexopoulos SP, Deshpande P (2019) Advances in clinical liver transplantation: expanding indications and improving peri-and post-transplant care. Curr Opin Organ Transplant.  https://doi.org/10.1097/mot.0000000000000626 CrossRefPubMedGoogle Scholar
  2. 2.
    Singh S, Swanson KL, Hathcock MA et al (2014) Identifying the presence of clinically significant hepatic involvement in hereditary haemorrhagic telangiectasia using a simple clinical scoring index. J Hepatol 61(1):124–131CrossRefGoogle Scholar
  3. 3.
    Felli E, Addeo P, Faitot F et al (2017) Liver transplantation for hereditary hemorrhagic telangiectasia: a systematic review. HPB (Oxford) 19(7):567–572CrossRefGoogle Scholar
  4. 4.
    International HHT Scientific Conference (2018) June 8–11, 2017, Dubrovnik, Croatia. Angiogenesis 1:111–167Google Scholar
  5. 5.
    Caballero F, Leal J, Puig M et al (2013) Organ donation and Rendu–Osler–Weber syndrome. Transplantation 95(7):e47–e48CrossRefGoogle Scholar

Copyright information

© Italian Society of Surgery (SIC) 2019

Authors and Affiliations

  1. 1.Department for the Treatment and Study of Abdominal Diseases and Abdominal TransplantationIRCCS-ISMETT (Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), UPMC (University of Pittsburgh Medical Center) ItalyPalermoItaly
  2. 2.Department of Surgery and Surgical and Medical SpecialtiesUniversity of CataniaCataniaItaly
  3. 3.Department of Diagnostic and Therapeutic ServicesIRCCS-ISMETT, UPMC ItalyPalermoItaly

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