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Role of local ablative techniques (Radiofrequency ablation and Irreversible Electroporation) in the treatment of pancreatic cancer

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Abstract

Thanks to continuous research and investment in technology, the ablation of tumors has become common. Through the application of different types of energy is possible to induce cellular injury of the neoplastic tissue, leading to cellular death. Radiofrequency ablation (RFA) and irreversible electroporation (IRE) represent the most applied ablative techniques on pancreatic cancer. RFA and IRE, causing necrosis and apoptosis of neoplastic cells, are able to destroy neoplastic tissue, to drastically modify the neoplastic microenvironment and, possibly, to stimulate both directly and indirectly the anti-tumor immune system. This article provides part of our experience with the application of RFA and IRE on pancreatic adenocarcinoma (PDAC).

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Authors and Affiliations

  1. General and Pancreatic Surgery Department, The Pancreas Institute, University of Verona Hospital Trust, Piazzale L.A. Scuro 10, 37134, Verona, Italy

    Salvatore Paiella, Roberto Salvia & Claudio Bassi

  2. Pancreatic Surgical Unit, Casa di Cura Pederzoli, Peschiera Del Garda, Verona, Italy

    Roberto Girelli, Isabella Frigerio & Alessandro Giardino

  3. Radiology Department, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy

    Mirko D’Onofrio

  4. Gastroenterology B Department, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy

    Giulia De Marchi

Authors
  1. Salvatore Paiella
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  2. Roberto Salvia
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  3. Roberto Girelli
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  4. Isabella Frigerio
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  5. Alessandro Giardino
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  6. Mirko D’Onofrio
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  7. Giulia De Marchi
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  8. Claudio Bassi
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Correspondence to Claudio Bassi.

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The authors declares that there is no conflict of interest regarding the publication of this paper.

Research involving human participants and/or animals

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Paiella, S., Salvia, R., Girelli, R. et al. Role of local ablative techniques (Radiofrequency ablation and Irreversible Electroporation) in the treatment of pancreatic cancer. Updates Surg 68, 307–311 (2016). https://doi.org/10.1007/s13304-016-0385-9

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  • DOI: https://doi.org/10.1007/s13304-016-0385-9

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