Updates in Surgery

, Volume 66, Issue 2, pp 101–108 | Cite as

Perfusion machines for liver transplantation: technology and multifunctionality

Review Article

Abstract

The reliability of machine perfusion (alternative to static cold storage) for the preservation of liver for transplantation has been well investigated in experimental models, by taking into account the temperature, oxygenation, flow, pressure, and settings of the machine or proposed circuit. Machine perfusion is considered by many researchers as a valid method for preserving organs. While circuits or machines for preservation have been described, no agreement has been reached concerning how these devices should be developed. The machines proposed to date are considered here to identify the technical and functional features necessary for a machine to have multifunctionality and adaptability to cater all the needs of preservation, according to the type and features of the liver to be transplanted, including marginal livers. The need to establish a uniform method for the use of this machine is also emphasized, to achieve a clinical protocol for its use.

Keywords

Preservation of liver Machine perfusion Hyperbaric oxygen Thermal conservation 

Abbreviations

HMP

Hypothermic machine perfusion

MP

Machine perfusion

NHBD

Non-heartbeating donor

DCDD

Donation after circulatory determination of death

SCS

Simple cold storage

Notes

Acknowledgments

This study was supported by a grant from Fondazione Cassa di Risparmio of the Republic of San Marino (RSM) and Fondazione Cassa di Risparmio of Ferrara (Italy).

Conflict of interest

The author has no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of FerraraFerraraItaly

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